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Published on: September 20, 2024
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Bioinformatics and systems-biology approach to identify common pathogenic mechanisms for COVID-19 and systemic lupus
Yinlan Wu1,2,3, Yanhong Li1,2,3, Yu Zhou4
1Department of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu, China.
Autoimmunity
|February 9, 2024
Summary
This study reveals shared molecular pathways and hub genes between Coronavirus disease 2019 (COVID-19) and systemic lupus erythematosus (SLE). These findings identify potential drug targets for treating COVID-19 and co-occurring SLE.
Area of Science:
- Immunology
- Genomics
- Pharmacology
Background:
- Coronavirus disease 2019 (COVID-19) shares clinical symptoms with systemic lupus erythematosus (SLE).
- The pathological similarities and treatment strategies for co-infected patients remain unclear.
- This study investigates potential shared pathogenesis between COVID-19 and SLE.
Purpose of the Study:
- To analyze potential similar pathogenesis between SLE and COVID-19.
- To explore possible drug regimens for SLE patients with COVID-19.
- To identify common molecular targets and therapeutic candidates.
Main Methods:
- Utilized bioinformatics and systems biology approaches.
- Analyzed common differentially expressed genes (DEGs) from COVID-19 and SLE transcriptome datasets.
- Performed functional enrichment, pathway analysis, and protein-protein interaction (PPI) analysis to identify hub genes.
Main Results:
- Identified 325 common DEGs between COVID-19 and SLE.
- Discovered shared functional changes, hub genes, pathways, and regulatory networks.
- Identified numerous candidate drugs through drug target matching for COVID-19 and/or SLE patients.
Conclusions:
- COVID-19 and SLE patients exhibit common hub genes, pathways, and regulatory networks.
- Identified potential therapeutic drugs based on shared molecular targets.
- Findings offer insights into treating COVID-19 and co-existing SLE.
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