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Bioinformatics and systems-biology approach to identify common pathogenic mechanisms for COVID-19 and systemic lupus

Yinlan Wu1,2,3, Yanhong Li1,2,3, Yu Zhou4

  • 1Department of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu, China.

Autoimmunity
|February 9, 2024
PubMed

Insights

This study reveals shared molecular pathways and hub genes between Coronavirus disease 2019 (COVID-19) and systemic lupus erythematosus (SLE). These findings identify potential drug targets for treating COVID-19 and co-occurring SLE.

Area of Science:

  • Immunology
  • Genomics
  • Pharmacology

Background:

  • Coronavirus disease 2019 (COVID-19) shares clinical symptoms with systemic lupus erythematosus (SLE).
  • The pathological similarities and treatment strategies for co-infected patients remain unclear.
  • This study investigates potential shared pathogenesis between COVID-19 and SLE.

Purpose of the Study:

  • To analyze potential similar pathogenesis between SLE and COVID-19.
  • To explore possible drug regimens for SLE patients with COVID-19.
  • To identify common molecular targets and therapeutic candidates.

Main Methods:

  • Utilized bioinformatics and systems biology approaches.
  • Analyzed common differentially expressed genes (DEGs) from COVID-19 and SLE transcriptome datasets.
  • Performed functional enrichment, pathway analysis, and protein-protein interaction (PPI) analysis to identify hub genes.

Main Results:

  • Identified 325 common DEGs between COVID-19 and SLE.
  • Discovered shared functional changes, hub genes, pathways, and regulatory networks.
  • Identified numerous candidate drugs through drug target matching for COVID-19 and/or SLE patients.

Conclusions:

  • COVID-19 and SLE patients exhibit common hub genes, pathways, and regulatory networks.
  • Identified potential therapeutic drugs based on shared molecular targets.
  • Findings offer insights into treating COVID-19 and co-existing SLE.
Abstract

Keywords:
Systemic lupus erythematosusbioinformaticscommon differentially expressed genescoronavirus disease 2019small molecule compound drugs

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