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Updated: Jul 4, 2025

Synthesis of pH Dependent Pyrazole, Imidazole, and Isoindolone Dipyrrinone Fluorophores using a Claisen-Schmidt Condensation Approach
Published on: June 10, 2021
A phenothiazine-functionalized pyridine-based AIEE-active molecule: a versatile molecular probe for highly sensitive
Dhandapani Vinayagam1, Karpagam Subramanian1
1Department of Chemistry, School of Advanced Sciences, Vellore Institute of Technology Vellore 632014 Tamil Nadu India skarpagam80@yahoo.com skarpagam@vit.ac.in +91-416-2202334 +91-416-2243092.
Abstract:
In this study, we designed and synthesized a novel compound (PTH-AB-PY) based on phenothiazine and pyridine moieties with aggregation-induced emission enhancement (AIEE) properties. The compound has shown exceptional selectivity and sensitivity towards ClO- ions with an impressive detection limit of 6.86 × 10-4 M. Its remarkable sensitivity arises from its effective inhibition of the photoinduced electron transfer (PET) mechanism. Job's plot analysis and high-resolution mass spectrometry (HR-MS) confirmed the 1 : 1 binding ratio between the compound and ClO-. The synthesized compound also exhibits higher sensitivity and fluorescence quenching towards the explosive species (picric acid), with a detection limit of around 1.44 × 10-6 M. Furthermore, our work was carried out for real-time water sample analysis to check ClO- and picric acid detection and high recovery rates (94 to 99%) were achieved. These findings highlight the potential of PTH-AB-PY as a promising molecular probe for ClO- ions and picric acid detection with various analytical and environmental applications.
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