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Updated: Jun 30, 2026
Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
Transcatheter aortic valve replacement in patients with chronic kidney disease: a multi-centre retrospective study
Mohammed Al Jarallah1, Salman Abdulsalam2, Rajesh Rajan1
1Department of Cardiology, Sabah Al Ahmed Cardiac Centre, Al Amiri Hospital, Kuwait City, Kuwait.
Insights
Chronic kidney disease (CKD) significantly increases mortality risk in patients undergoing transcatheter aortic valve replacement (TAVR). This study highlights the importance of considering CKD in TAVR outcomes.
Area of Science:
- Cardiology
- Nephrology
- Public Health
Background:
- Chronic kidney disease (CKD) is a frequent comorbidity in patients undergoing transcatheter aortic valve replacement (TAVR).
- Limited studies have reported on the association between baseline CKD and mortality outcomes in TAVR patients.
Purpose of the Study:
- To determine the prevalence of CKD in TAVR patients.
- To analyze the procedural outcomes of TAVR patients with and without baseline CKD.
Main Methods:
- Retrospective observational study at 43 public hospitals in Hong Kong.
- Included severe aortic stenosis patients undergoing TAVR between 2010 and 2019.
- Patients were grouped based on the presence of baseline CKD.
Main Results:
- 499 patients were analyzed; CKD was associated with higher mortality rates (10% vs. 4.1%, P=0.04%).
- Hypertension was more prevalent in CKD patients (82.8%).
- Gout (OR=5.96) and hypertension (OR=2.83) were significantly associated with chronic renal failure (CRF).
Conclusions:
- Baseline CKD is a significant predictor of long-term mortality in patients with severe aortic stenosis undergoing TAVR.
- CKD management is crucial for improving TAVR patient outcomes.
Background:
Chronic kidney disease (CKD) is a common comorbid condition in patients undergoing transcatheter aortic valve replacement (TAVR). Reported outcome studies on the association of baseline CKD and mortality is currently limited.
Objectives:
To determine the prevalence of chronic kidney disease in patients undergoing TAVR and analyse their overall procedural outcomes.
Methods:
This retrospective observational study was conducted at 43 publicly funded hospitals in Hong Kong. Severe aortic stenosis patients undergoing TAVR between the years 2010 and 2019 were enroled in the study. Two groups were identified according to the presence of baseline chronic kidney disease.
Results:
A total of 499 patients (228, 58.6% men) were enroled in the study. Baseline hypertension was more prevalent in patients with CKD (82.8%; P=0.003). As for primary end-points, mortality rates of CKD patients were significantly higher compared to non-CKD patients (10% vs. 4.1%; P=0.04%). Gout and hypertension were found to be significantly associated with CRF. Patients with gout were nearly six times more likely to have CRF than those without gout (odds ratio = 5.96, 95% CI = 3.12-11.29, P<0.001). Patients with hypertension had three times the likelihood of having CRF compared to those without hypertension (odds ratio=2.83, 95% CI=1.45-6.08, P=0.004).
Conclusion:
In patients with severe aortic stenosis undergoing TAVR, baseline CKD significantly contributes to mortality outcomes at long-term follow up.
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