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Related Concept Videos

Hypersensitivities01:30

Hypersensitivities

642
Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
642
Transcytosis of IgG01:15

Transcytosis of IgG

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Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
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Related Experiment Video

Updated: Jul 4, 2025

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
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Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

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Hyper-IgE syndrome: a case report.

Tirth Dave1, Fatema Ali Asgar Tashrifwala2, Umme Salma Rangwala3

  • 1Bukovinian State Medical University, Chernivtsi, Ukraine.

Annals of Medicine and Surgery (2012)
|February 9, 2024
PubMed
Summary
This summary is machine-generated.

Hyper-IgE syndrome (HIES), or Job syndrome, is a rare immunodeficiency. Early diagnosis and STAT3 gene mutation identification are key for managing recurrent infections and improving patient outcomes.

Keywords:
elevated IgE levelshyper-IgE syndromejob syndromeprimary immunodeficiency

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Area of Science:

  • Immunology
  • Genetics
  • Clinical Medicine

Background:

  • Hyper-IgE syndrome (HIES), also known as Job syndrome, is a rare primary immunodeficiency.
  • Characterized by elevated serum IgE, recurrent infections, and diverse clinical manifestations.

Observation:

  • A 37-year-old male diagnosed at age 2 with HIES due to recurrent Staphylococcal cold abscesses.
  • Presented with eczema, frequent bacterial infections, mucocutaneous candidiasis, and physical abnormalities.

Findings:

  • Diagnostic markers included elevated IgE, eosinophilia, and a confirmed STAT3 gene mutation.
  • Treatment involved supportive care and antibiotics; blood tests showed anemia and elevated ESR; imaging revealed pulmonary nodules.

Implications:

  • Highlights the critical role of early diagnosis and prompt infection management in HIES.
  • Emphasizes the need for further research into HIES pathogenesis and targeted therapies.
  • Genetic testing, specifically STAT3 sequencing, is vital for confirming HIES diagnosis.