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Ulcerative colitis and pyoderma gangrenosum refractory to treatment successfully managed with pentoxifylline: a case
Miguel A Jiménez-Luévano1, Ana E Jiménez-Partida1, Miguel A Jiménez-Partida1
1Servicio de Gastroenterología, Hospital Regional 'Dr. Valentín Gómez Farías', ISSSTE Zapopan.
Introduction And Importance:
Pyoderma gangrenosum is an unusual inflammatory pathology, with neutrophilic dermatosis, of unknown etiology. It is associated with diseases such as bowel disease. Generally, it is treated with anti-inflammatory drugs, corticosteroids, immunosuppressants, and antibodies against tumor necrosis factor, but relapse and adverse effects are persistent. Pentoxifylline is a drug with immunoregulatory and anti-inflammatory properties.
Case Presentation:
A 47-year-old male with a diagnosis of ulcerative colitis initially managed favorably for 7 years with mesalazine. At 3 years of treatment, he presented a sudden ulcer that affected skin and subcutaneous tissue (13×10 cm) in the lower right limb. During the last 2 years, he was treated with mesalazine and infliximab with partial results and permanent relapses. Therefore, pentoxifylline was added to his treatment.
Clinical Discussion:
The justification for the addition of pentoxifylline is mainly its action as an inhibitor of Nuclear Factor-kappa Beta (NF-κB) transcription, which stimulates the expression of proinflammatory interleukin genes such as IL-1, IL-6, IL- 8, and TNF-α and showing immunoregulatory and antioxidant activities.
Conclusion:
With pentoxifylline, this lesion healed at 6 weeks without relapses after 2 years.
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