Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Insufficient Sleep and Sleep Deprivation01:13

Insufficient Sleep and Sleep Deprivation

143
Insufficient sleep refers to not getting the recommended amount of sleep for optimal functioning, even if it's just slightly less than needed. Sleep insufficiency may occur due to lifestyle choices, such as staying up late for social events or work, resulting in routinely getting less sleep than required. For example, consistently sleeping 6 hours when the body needs 7-9 hours can lead to cumulative effects on health and well-being.
Sleep deprivation is a more severe form of sleep loss...
143
Factors Affecting Renal Clearance: Renal Impairment01:17

Factors Affecting Renal Clearance: Renal Impairment

95
Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
95
Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response01:15

Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response

61
Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
61
Renal Failure: Dose Adjustments01:11

Renal Failure: Dose Adjustments

89
In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
89
Nephrons01:10

Nephrons

2.4K
The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...
2.4K
Renal Drug Excretion: Tubular Reabsorption01:25

Renal Drug Excretion: Tubular Reabsorption

173
Tubular reabsorption, a process occurring post-glomerular filtration of drugs in the renal tubule, is a critical determinant of drug half-life. During the process of renal excretion, as the glomerular filtrate progresses to the distal convoluted tubule (DCT), drugs that are highly permeable, lipophilic, and nonionized undergo passive reabsorption from the tubular fluid into the surrounding peritubular capillaries. This reabsorption process restricts their elimination through the kidneys. This...
173

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impact of Vascular Access Type and Obesity on Long-Term Thrombosis and Access Failure in Hemodialysis: A Real-World Cohort Study from the TriNetX Global Collaborative Network.

Biomedicines·2026
Same author

Redox Network Failure in Chronic Kidney Disease: Hydrogen Sulfide Deficiency, Reactive Sulfur Species Dysregulation and the Uremic Toxin-AhR-Mitochondrial Axis.

Antioxidants (Basel, Switzerland)·2026
Same author

Reduced Serum Uric Acid and Albumin Levels in Patients with Migraine: A Cross-Sectional Study.

Journal of clinical medicine·2026
Same author

Circadian Influences on Chronic Kidney Disease Progression: Molecular Signaling Pathways of Melatonin and Their Therapeutic Potential.

Pharmaceuticals (Basel, Switzerland)·2026
Same author

α7nAChR agonist GTS-21 ameliorates sepsis-induced acute kidney injury via MEF2/PGC-1α/HO-1 axis in mice.

Clinical and translational medicine·2026
Same author

Expanding Outcomes Beyond Chronic Kidney Disease-Mineral and Bone Disorder: A Propensity Score-Matched Analysis of Parathyroidectomy versus Calcimimetics in Dialysis Patients with Secondary Hyperparathyroidism.

International journal of medical sciences·2026
Same journal

A Nomogram Model for Predicting Moderate to Severe OSA in Western China: A Retrospective Analysis.

Nature and science of sleep·2026
Same journal

Content Validity and Psychometric Evaluation of the Idiopathic Hypersomnia Severity Scale (IHSS) in Adults with Idiopathic Hypersomnia.

Nature and science of sleep·2026
Same journal

The Prognostic Value of Early Treatment Factors for Cognitive Behavioral Therapy for Insomnia (CBT-I) Outcomes.

Nature and science of sleep·2026
Same journal

Follow-up Study on the Sleep Status of Anti-Epidemic Staff: A Study Based on Wearable Sleep Trackers.

Nature and science of sleep·2026
Same journal

Prevalence of Insomnia in Healthcare Profession - PIHEP Study: A Large-Scale National Study in Vietnam.

Nature and science of sleep·2026
Same journal

Validation of the Richards-Campbell Sleep Questionnaire Against Actigraphy in Hospitalized Patients and Its Association with Delirium Risk.

Nature and science of sleep·2026
See all related articles

Related Experiment Video

Updated: Jul 4, 2025

Noninvasive, High-throughput Determination of Sleep Duration in Rodents
07:33

Noninvasive, High-throughput Determination of Sleep Duration in Rodents

Published on: April 18, 2018

7.8K

Sleep Duration and Kidney Function - Does Weekend Sleep Matter?

Chia-Chao Wu1,2, Pei-Lin Yang3, Li-Ting Kao4,5,6

  • 1Division of Nephrology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.

Nature and Science of Sleep
|February 9, 2024
PubMed
Summary
This summary is machine-generated.

Longer weekend sleep, especially after short weekday sleep, is linked to declining kidney function. This highlights the importance of consistent sleep duration for kidney health.

Keywords:
CKDchronic kidney diseaseeGFRestimated glomerular filtration ratekidney functionnational health and nutrition examination surveyweekend sleep duration

More Related Videos

A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice
06:23

A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice

Published on: September 22, 2020

5.4K
A High-performance Liquid Chromatography Measurement of Kynurenine and Kynurenic Acid: Relating Biochemistry to Cognition and Sleep in Rats
07:04

A High-performance Liquid Chromatography Measurement of Kynurenine and Kynurenic Acid: Relating Biochemistry to Cognition and Sleep in Rats

Published on: August 19, 2018

10.5K

Related Experiment Videos

Last Updated: Jul 4, 2025

Noninvasive, High-throughput Determination of Sleep Duration in Rodents
07:33

Noninvasive, High-throughput Determination of Sleep Duration in Rodents

Published on: April 18, 2018

7.8K
A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice
06:23

A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice

Published on: September 22, 2020

5.4K
A High-performance Liquid Chromatography Measurement of Kynurenine and Kynurenic Acid: Relating Biochemistry to Cognition and Sleep in Rats
07:04

A High-performance Liquid Chromatography Measurement of Kynurenine and Kynurenic Acid: Relating Biochemistry to Cognition and Sleep in Rats

Published on: August 19, 2018

10.5K

Area of Science:

  • Nephrology
  • Sleep Medicine
  • Public Health

Background:

  • Weekend sleep duration is associated with various health outcomes, including mortality.
  • The specific impact of weekend sleep patterns on chronic kidney disease (CKD) remains under-investigated.

Purpose of the Study:

  • To investigate the association between weekend sleep duration and kidney function.
  • To analyze how different weekday and weekend sleep durations correlate with estimated glomerular filtration rate (eGFR).

Main Methods:

  • Cross-sectional study utilizing data from the 2017-2018 National Health and Nutrition Examination Survey.
  • Inclusion of 5362 participants categorized by sleep duration (short: ≤6h, normal: 6-9h, long: ≥9h) on weekdays and weekends.
  • Stratified multivariable linear regression analysis to assess associations with renal function, adjusting for covariates.

Main Results:

  • Weekend sleep durations of 9 hours or more were associated with decreased eGFR levels (2.8–6.4 mL/min/1.73 m²).
  • The most significant eGFR decline was observed in individuals with short weekday sleep and long weekend sleep (sWK-lWD).
  • For the sWK group, each additional hour of weekend sleep correlated with a 1.1 mL/min/1.73 m² decrease in eGFR.

Conclusions:

  • Longer weekend sleep duration is linked to reduced kidney function (eGFR).
  • Potential underlying mechanisms include dysregulation of behaviors, metabolism, or biological functions.
  • Further research is needed to elucidate the mediators connecting long weekend sleep and CKD.