Related Experiment Video

Updated: May 6, 2026

Detection of MicroRNA Expression in the Kidneys of Immunoglobulin A Nephropathic Mice
05:39

Detection of MicroRNA Expression in the Kidneys of Immunoglobulin A Nephropathic Mice

Published on: July 8, 2020

1.9K

Microangiopathy associated with poor outcome of immunoglobulin A nephropathy: a cohort study and meta-analysis

Lei Dong1, Yuncan Hu2, Dan Yang1

  • 1Division of Nephrology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Clinical Kidney Journal
|February 9, 2024
PubMed
Abstract

Insights

Microangiopathy (MA) lesions in immunoglobulin A nephropathy (IgAN) predict worse kidney outcomes. This finding was confirmed in a large meta-analysis, highlighting MA as a key risk factor for IgAN progression.

Area of Science:

  • Nephrology
  • Pathology
  • Clinical Medicine

Background:

  • Microangiopathy (MA) lesions are observed in IgA nephropathy (IgAN).
  • Their role in IgAN progression and renal function decline is debated.
  • This study investigates the association between MA and IgAN outcomes.

Purpose of the Study:

  • To investigate the role of microangiopathy (MA) lesions in immunoglobulin A nephropathy (IgAN) progression.
  • To analyze the association between MA and kidney outcomes in a Chinese cohort.
  • To validate findings through a systematic meta-analysis.

Main Methods:

  • A cohort study of 450 IgAN patients confirmed by renal biopsy.
  • Clinical data collection and analysis.
  • Systematic literature search of PubMed and Web of Science for relevant studies.

Main Results:

  • IgAN patients with MA were older, with higher blood pressure, proteinuria, worse kidney function, and elevated uric acid.
  • MA group showed more global glomerulosclerosis and interstitial fibrosis/tubular atrophy.
  • MA lesions independently predicted adverse kidney outcomes (aHR 2.115) and were validated in a meta-analysis (aRR 2.87).

Conclusions:

  • Microangiopathy lesions are significant predictors of disease progression in IgAN.
  • MA offers prognostic value beyond the established Oxford MEST-C score.
  • MA lesions are a valuable biomarker for identifying high-risk IgAN patients.
Keywords:
IgA nephropathycohort studymeta-analysismicroangiopathyoutcome

More Related Videos

Author Spotlight: Investigating the Potential of Chinese Herbal Medicinal Active Dioscin in Treating IgA Nephropathy14:18

Author Spotlight: Investigating the Potential of Chinese Herbal Medicinal Active Dioscin in Treating IgA Nephropathy

Published on: October 13, 2023

1.8K
Mechanism of Kemeng Fang's Inhibition of Podocyte Apoptosis in Rats with Membranous Nephropathy through the PI3K/AKT Signaling Pathway07:15

Mechanism of Kemeng Fang's Inhibition of Podocyte Apoptosis in Rats with Membranous Nephropathy through the PI3K/AKT Signaling Pathway

Published on: August 23, 2024

416

Related Concept Videos

Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
1.2K
Nephrotic Syndrome II : Assessment and Medical Management01:26

Nephrotic Syndrome II : Assessment and Medical Management

IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
409
Nephrotic Syndrome III : Nursing Management01:24

Nephrotic Syndrome III : Nursing Management

Nursing management for nephrotic syndrome adapts as the disease progresses, with strategies evolving to address advancing symptoms and complications.Early-Stage Management In the early stages, nursing interventions for nephrotic syndrome resemble those used in managing acute glomerulonephritis, focusing on symptom monitoring, fluid balance, and managing mild to moderate edema.Vital Signs: Regularly monitor blood pressure, pulse, respiratory rate, and temperature to promptly identify...
549
Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
2.3K
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
559
Diabetic Nephropathy01:28

Diabetic Nephropathy

Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration...
32