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Bacterial Proteins and Peptides as Potential Anticancer Agents: A Novel Search for Protein-based Therapeutics

Mahitha Pyla1, Sanjana Kankipati1, Bapatla Sumithra1

  • 1Department of Biotechnology, Chaitanya Bharathi Institute of Technology (CBIT), Gardipe, Hyderabad - 500075, Telangana, India.

Current Medicinal Chemistry
|February 9, 2024
PubMed

Insights

Bacterial proteins and peptides show promise as novel anti-cancer agents. This review details their characteristics and mechanisms, highlighting their potential in cancer therapy and ongoing research.

Area of Science:

  • Oncology
  • Microbiology
  • Pharmacology

Background:

  • Tumor diseases are a leading cause of death globally.
  • Chemotherapy challenges and drug resistance necessitate new anti-cancer strategies.
  • Bacterial proteins and peptides represent a significant class of potential anti-cancer drugs.

Purpose of the Study:

  • To review recent advancements in anti-cancer bacterial peptides.
  • To elucidate the characteristics and mechanisms of action of these peptides.
  • To highlight peptides currently used in cancer therapy and those under investigation.

Main Methods:

  • Literature review of scientific databases.
  • Analysis of characteristics and mechanisms of anti-cancer bacterial peptides.
  • Compilation of data on clinical and preclinical studies.

Main Results:

  • Several bacterial peptides are effective anti-cancer agents.
  • Some peptides are already in clinical use, while others are in early research stages.
  • Diverse mechanisms of action are observed among these peptides.

Conclusions:

  • Bacterial peptides offer a promising avenue for developing new cancer treatments.
  • Further research is crucial to fully harness their therapeutic potential.
  • Understanding their mechanisms can guide the development of more effective anti-cancer therapies.
Keywords:
Canceranti-cancer antibioticsanti-cancer drugsanti-cancer enzymesbacterial peptidesbacterial toxinsbacteriocinsribosomal peptides.

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