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High-throughput Identification of Bacteria Repellent Polymers for Medical Devices
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Fast and Stable Antibacterial Coating of Photosensitive Aggregation-Induced Emission Luminogens for Disinfection on

Mian Chen1, Ruihua Dong2, Jiayi Song1

  • 1Innovation Research Center for AIE Pharmaceutical Biology, Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, the NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences and the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, 511436, China.

Advanced Healthcare Materials
|February 9, 2024
PubMed
Summary
This summary is machine-generated.

Aggregation-induced emission luminogens (AIEgens) offer potent antibacterial properties by generating reactive oxygen species (ROS). These AIEgen coatings effectively eliminate bacteria, including multidrug-resistant strains, with excellent safety and stability for medical device disinfection.

Keywords:
AIEgen‐covered coatingaggregation‐induced emissionantibacterial abilitymultidrug‐resistant (MDR) mutants

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Biomedical Engineering

Background:

  • Aggregation-induced emission luminogens (AIEgens) are advanced photosensitizers with significant potential in antibacterial applications.
  • AIEgens effectively generate reactive oxygen species (ROS), crucial for combating bacterial infections.

Purpose of the Study:

  • To develop and evaluate AIEgen-based coatings for robust and safe antibacterial applications.
  • To investigate the efficacy of AIEgens against pathogenic Gram-positive bacteria and their multidrug-resistant (MDR) mutants.

Main Methods:

  • Plasma-assisted electrostatic self-assembly was employed to deposit AIEgens (TTCPy-PF6 and TTCPy-Br) onto various solid substrates.
  • The antibacterial activity, cytotoxicity, hemolysis, and inflammation associated with the AIEgen-coated surfaces were assessed.

Main Results:

  • The AIEgen-covered coatings demonstrated effective elimination of Gram-positive bacteria and MDR mutants.
  • The coatings exhibited negligible cytotoxicity, hemolysis, and inflammation, indicating excellent biocompatibility.
  • The antibacterial effect was sustained over time, attributed to ROS-mediated bacterial disruption.

Conclusions:

  • AIEgen-based coatings present a promising strategy for high-efficacy, biocompatible, and stable antibacterial surfaces.
  • These coatings offer advantages over traditional antibiotics, reducing the risk of antibiotic pollution.
  • The developed AIEgen coatings are suitable for the disinfection of medical devices, enhancing safety and preventing infections.