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Updated: Jul 4, 2025

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Published on: June 26, 2020
Association between polymorphisms of the DNA repair genes RAD51 and OGG1 and risk of cardiovascular disease
Amar Alomair1, Abdullah Alamri1, Jilani Shaik1
1Genome Research Chair, Department of Biochemistry, College of Science, King Saud University, Riyadh 11451, Kingdom of Saudi Arabia.
Genetic variants in DNA repair genes impact cardiovascular disease (CVD) risk. The RAD51 gene polymorphism rs1801321 shows a significant association with CVD, offering potential for early detection and treatment strategies.
Area of Science:
- Genetics
- Cardiovascular Medicine
- Molecular Biology
Background:
- Cardiovascular disease (CVD) is a major global cause of mortality.
- Single-nucleotide polymorphisms (SNPs) in DNA repair genes are implicated in CVD.
- Limited genotyping data exists for specific populations.
Purpose of the Study:
- To investigate the association between genetic variants in RAD51 recombinase (RAD51) and 8-oxoguanine DNA glycosylase (OGG1) and CVD.
- To provide valuable genotyping data for RAD51 and OGG1 polymorphisms.
Main Methods:
- Genotyping of 240 blood samples (120 CVD cases, 120 controls) using TaqMan genotyping.
- Statistical analysis of genotype data.
- Data collection via questionnaires and medical record confirmation.
Main Results:
- The OGG1 polymorphism rs1052133 showed no significant association with CVD.
- The RAD51 polymorphism rs1801321 demonstrated a significant association with CVD.
- Genotyping data for these polymorphisms were successfully generated.
Conclusions:
- The RAD51 polymorphism rs1801321 is significantly associated with cardiovascular disease.
- Further research with larger sample sizes is recommended to validate these findings.
- This association may aid in early CVD identification and treatment decisions.
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