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Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain
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Methotrexate for juvenile idiopathic arthritis
Joachim Tan1,2, William D Renton2,3,4, Samuel L Whittle2,5
1Department of Rheumatology, Children's Health Queensland, South Brisbane, Australia.
The Cochrane Database of Systematic Reviews
|February 9, 2024
Summary
Methotrexate may improve treatment response in juvenile idiopathic arthritis (JIA) but shows little effect on pain. Serious adverse events are rare, supporting its use as a disease-modifying antirheumatic drug (DMARD) in JIA management.
Area of Science:
- Pediatric Rheumatology
- Pharmacology
- Clinical Trials
Background:
- Juvenile idiopathic arthritis (JIA) is the most prevalent rheumatic condition in childhood.
- Methotrexate is a widely used disease-modifying antirheumatic drug (DMARD) with broad immunomodulatory effects.
- This review is an update of a 2001 Cochrane review, supporting a living guideline for JIA.
Conclusions:
- Methotrexate may enhance treatment response in JIA but has minimal impact on pain and well-being compared to placebo.
- Evidence suggests limited additional benefit of methotrexate when combined with intra-articular glucocorticoids for oligoarticular JIA.
- Methotrexate appears to be a safe option with rare serious adverse events, supporting its role in JIA management.
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