Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Myasthenia Gravis: Overview and Treatment01:20

Myasthenia Gravis: Overview and Treatment

1.4K
Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
1.4K
Seizures: Classification01:13

Seizures: Classification

356
Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
356
Myasthenia Gravis: Diagnostic Tests01:15

Myasthenia Gravis: Diagnostic Tests

840
Myasthenia gravis is an autoimmune condition affecting neuromuscular transmission, causing generalized weakness in skeletal muscles. Initial diagnoses rely on patients' signs, symptoms, and medical history. The challenge lies in distinguishing myasthenia from other muscular dystrophies. An important diagnostic feature is the significant improvement of symptoms after administering anticholinesterase inhibitors.
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...
840
Mania and Antimanic Drugs: Overview01:24

Mania and Antimanic Drugs: Overview

181
Mania, a psychological condition characterized by elevated mood, increased energy, and reduced sleep need, is part of the bipolar disorder cycle. The exact cause of mania isn't entirely known, but it is thought to be a combination of genetic, environmental, and neurological factors. Bipolar disorder involves alternating manic and depressive episodes. Mood stabilizers like lithium, antipsychotics, and anticonvulsants help manage these episodes. Lithium carbonate is particularly effective as...
181
Disorders of the Skeletal Muscle01:28

Disorders of the Skeletal Muscle

948
The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
948
Antiepileptic Drugs: Glutamate Antagonists01:14

Antiepileptic Drugs: Glutamate Antagonists

357
Glutamate is a fundamental neurotransmitter in the central nervous system, playing a vital role in neuronal communication and various cognitive processes. Glutamate stands as the principal excitatory neurotransmitter in the brain. Its presence is crucial for the communication between neurons, underpinning essential processes such as synaptic transmission, neuronal excitability, and plasticity. These functions are vital for higher-order cognitive processes, including learning and memory. The...
357

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Peri-ictal magnetic resonance imaging findings in pediatric seizures: a scoping review on pearls and pitfalls from a heterogeneous population.

Translational pediatrics·2026
Same author

Neuropsychological functioning and progression in Lafora disease.

Epilepsia·2026
Same authorSame journal

Expanding the electroclinical spectrum of TANC2-related disorders: Lennox-Gastaut syndrome and related developmental epileptic phenotypes.

Epilepsia open·2026
Same author

Global Socioeconomic Context and Brain Ageing in Epilepsy: an ENIGMA-Epilepsy study.

medRxiv : the preprint server for health sciences·2026
Same author

Stroke or Seizure? Diagnostic Role of Neuroimaging in Acute Neurologic Mimics.

NeuroSci·2026
Same author

Gut-Brain Axis Modulation by Short-Chain Fatty Acids Exerts Disease-Modifying Effects in a Murine Model of Drug-Resistant Epilepsy.

Annals of neurology·2026

Related Experiment Video

Updated: Jul 4, 2025

Muscle Velocity Recovery Cycles to Examine Muscle Membrane Properties
08:27

Muscle Velocity Recovery Cycles to Examine Muscle Membrane Properties

Published on: February 19, 2020

14.2K

Myoclonus: Differential diagnosis and current management.

Antonella Riva1,2, Gianluca D'Onofrio1,2, Edoardo Ferlazzo3,4

  • 1Department of Neurosciences Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, Genoa, Italy.

Epilepsia Open
|February 9, 2024
PubMed
Summary

Myoclonus, brief shock-like jerks, can indicate various conditions. Understanding its neurophysiology and classification is crucial for accurate diagnosis and effective treatment, especially in epilepsy.

Keywords:
electroclinical featuresepilepsymyoclonusneurophysiologynosology

More Related Videos

Modeling Myotonic Dystrophy 1 in C2C12 Myoblast Cells
09:39

Modeling Myotonic Dystrophy 1 in C2C12 Myoblast Cells

Published on: July 29, 2016

15.4K
Author Spotlight: Studying Clinical Characters and Epilepsy Outcomes After Frontal Disconnection in Patients with MOGHE
06:04

Author Spotlight: Studying Clinical Characters and Epilepsy Outcomes After Frontal Disconnection in Patients with MOGHE

Published on: August 16, 2024

842

Related Experiment Videos

Last Updated: Jul 4, 2025

Muscle Velocity Recovery Cycles to Examine Muscle Membrane Properties
08:27

Muscle Velocity Recovery Cycles to Examine Muscle Membrane Properties

Published on: February 19, 2020

14.2K
Modeling Myotonic Dystrophy 1 in C2C12 Myoblast Cells
09:39

Modeling Myotonic Dystrophy 1 in C2C12 Myoblast Cells

Published on: July 29, 2016

15.4K
Author Spotlight: Studying Clinical Characters and Epilepsy Outcomes After Frontal Disconnection in Patients with MOGHE
06:04

Author Spotlight: Studying Clinical Characters and Epilepsy Outcomes After Frontal Disconnection in Patients with MOGHE

Published on: August 16, 2024

842

Area of Science:

  • Neurology
  • Neurophysiology

Background:

  • Myoclonus is defined as brief, non-rhythmic jerk movements.
  • Etiologies range from self-limited to progressive disorders, including encephalopathies.
  • Myoclonus is a common manifestation of epilepsy, presenting diverse clinical features.

Purpose of the Study:

  • To provide an updated overview of myoclonus neurophysiology and nosology.
  • To explore electroclinical features of myoclonus in specific epileptic syndromes.
  • To offer practical guidance for clinicians and researchers in diagnosis and treatment.

Main Methods:

  • Review of current literature and expert consensus.
  • Exploration of neurophysiological classification based on generator location.
  • Analysis of clinical patterns, EMG, and EEG correlates.

Main Results:

  • Myoclonus classification aids in understanding clinical presentation and guiding therapy.
  • Investigated the multifaceted role of myoclonus in epilepsy.
  • Highlighted the importance of electroclinical features in genetically determined epileptic syndromes.

Conclusions:

  • Accurate classification and understanding of myoclonus neurophysiology are essential for effective management.
  • Further investigation into specific epileptic syndromes is warranted.
  • This review provides a framework for improved diagnostic and therapeutic strategies for myoclonus.