Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Positron Emission Tomography01:29

Positron Emission Tomography

4.2K
Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...
4.2K
Radiological Investigation III: Pulmonary Angiogram and PET Scan01:13

Radiological Investigation III: Pulmonary Angiogram and PET Scan

92
Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
92
Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

120
Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
120

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Canadian Society Breast Imaging Position Statement on Mammographic Breast Density and Supplemental Screening.

Journal of breast imaging·2026
Same author

Improved Edge Pixel Resolution in Modular PET Detectors with Partly Segmented Light Guides.

Sensors (Basel, Switzerland)·2025
Same author

Node Reporting and Data System in Focus: Advancing Precision in Axillary Staging for Breast Cancer.

Radiology·2025
Same author

Effect of High Zn Concentration on the Structural, Electrical, and Magnetic Properties of Zn-Doped Yttrium Iron Garnet Nanoparticles.

ACS omega·2025
Same author

Characterization of microbubble cavitation in theranostic ultrasound-mediated blood-brain barrier opening for gene delivery.

Journal of controlled release : official journal of the Controlled Release Society·2025
Same author

T2 Hyperintense Lesions on Breast MRI - Is the Assumption of Benignity Justified?

Canadian Association of Radiologists journal = Journal l'Association canadienne des radiologistes·2025

Related Experiment Video

Updated: Jul 4, 2025

Detection of Architectural Distortion in Prior Mammograms via Analysis of Oriented Patterns
13:44

Detection of Architectural Distortion in Prior Mammograms via Analysis of Oriented Patterns

Published on: August 30, 2013

42.9K

Breast Cancer Detection Using a Low-Dose Positron Emission Digital Mammography System.

Vivianne Freitas1, Xuan Li1, Anabel Scaranelo1

  • 1From the Temerty Faculty of Medicine, Joint Department of Medical Imaging, University Health Network, Sinai Health System, Women's College Hospital, University of Toronto, 610 University Ave, Toronto, ON, Canada M5G 2M9 (V.F., A.S., F.A., S.K., S.G.); Department of Biostatistics, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada (X.L.); Thunder Bay Regional Health Research Institute, Thunder Bay, Canada (S.T., O.B., A.R.); Lakehead University, Thunder Bay, Canada (O.B., B.B., A.R.); Radialis Inc, Thunder Bay, Canada (O.B., B.B., B.K., S.P., C.A.M., M.W., K.O.O.); Institute of Biomedical Engineering, University of Toronto, Toronto, Canada (C.A.M.); and Posluns Centre for Image-Guided Innovation and Therapeutic Intervention, The Hospital for Sick Children, Toronto, Canada (C.A.M.).

Radiology. Imaging Cancer
|February 9, 2024
PubMed
Summary

Low-dose positron emission mammography (PEM) shows feasibility in detecting invasive breast cancer concurrently with MRI. This imaging tool holds promise for breast cancer diagnosis, though larger trials are needed.

Keywords:
Invasive Breast CancerMRIOncologyPositron Emission Digital Mammography

More Related Videos

A Basic Positron Emission Tomography System Constructed to Locate a Radioactive Source in a Bi-dimensional Space
14:19

A Basic Positron Emission Tomography System Constructed to Locate a Radioactive Source in a Bi-dimensional Space

Published on: February 1, 2016

8.6K
Tracking the Mammary Architectural Features and Detecting Breast Cancer with Magnetic Resonance Diffusion Tensor Imaging
15:48

Tracking the Mammary Architectural Features and Detecting Breast Cancer with Magnetic Resonance Diffusion Tensor Imaging

Published on: December 15, 2014

22.5K

Related Experiment Videos

Last Updated: Jul 4, 2025

Detection of Architectural Distortion in Prior Mammograms via Analysis of Oriented Patterns
13:44

Detection of Architectural Distortion in Prior Mammograms via Analysis of Oriented Patterns

Published on: August 30, 2013

42.9K
A Basic Positron Emission Tomography System Constructed to Locate a Radioactive Source in a Bi-dimensional Space
14:19

A Basic Positron Emission Tomography System Constructed to Locate a Radioactive Source in a Bi-dimensional Space

Published on: February 1, 2016

8.6K
Tracking the Mammary Architectural Features and Detecting Breast Cancer with Magnetic Resonance Diffusion Tensor Imaging
15:48

Tracking the Mammary Architectural Features and Detecting Breast Cancer with Magnetic Resonance Diffusion Tensor Imaging

Published on: December 15, 2014

22.5K

Area of Science:

  • Oncology
  • Medical Imaging
  • Radiology

Background:

  • Breast cancer diagnosis relies on accurate imaging techniques.
  • Magnetic Resonance Imaging (MRI) is a standard tool, but complementary methods are explored.
  • Positron Emission Mammography (PEM) offers functional imaging insights.

Purpose of the Study:

  • To assess the feasibility of low-dose positron emission mammography (PEM) alongside MRI for breast cancer detection.
  • To determine the capability of low-dose PEM in identifying the local extent of breast cancer.
  • To evaluate the diagnostic performance of PEM in conjunction with MRI.

Main Methods:

  • Prospective study involving 25 female participants with newly diagnosed breast cancer.
  • Low-dose 18F-FDG PEM performed concurrently with breast MRI.
  • PEM images reviewed by two radiologists at 1 and 4 hours post-injection, correlated with histopathology.
  • Detection accuracy and lesion detection efficacy compared between PEM and MRI.

Main Results:

  • Low-dose PEM identified 96% of cancers (24 of 25), including 19 invasive and five in situ diseases.
  • Comparable detection performance was observed even after 3 hours of radiotracer uptake.
  • PEM detected fewer false-positive additional lesions compared to MRI (16% vs 62%, P = .14).
  • Three additional in situ grade 2 lesions were missed by PEM.

Conclusions:

  • Low-dose PEM demonstrates feasibility as an adjunct tool for detecting invasive breast cancer.
  • This imaging modality shows potential as a promising tool in breast cancer diagnosis.
  • Further large-scale clinical trials are necessary to validate these preliminary findings.