Related Experiment Video
Updated: Jul 4, 2025
Real-Time, Two-Color Stimulated Raman Scattering Imaging of Mouse Brain for Tissue Diagnosis
Published on: February 1, 2022
[Intraoperative stimulated Raman histology for personalized brain tumor surgery]
Anna-Katharina Meißner1, Roland Goldbrunner1, Volker Neuschmelting2
1Klinik für allgemeine Neurochirurgie, Zentrum für Neurochirurgie, Medizinische Fakultät und Universitätsklinik Köln, Universität zu Köln, Kerpener Str. 62, 50937, Köln, Deutschland.
Background:
In brain tumor surgery a personalized surgical approach is crucial to achieve a maximum safe tumor resection. The extent of resection decisively depends on the histological diagnosis. Stimulated Raman histology (SRH), a fiber laser-based optical imaging method, offers the possibility for evaluation of an intraoperative diagnosis in a few minutes.
Objective:
To provide an overview on the applications of SRH in neurosurgery and transference of the technique to other surgical disciplines.
Methods:
Description of the technique and review of the current literature on SRH.
Results:
The SRH technique was successfully used in multiple neuro-oncological tumor entities. Initial pilot projects showed the potential for analysis of extracranial tumors.
Conclusion:
The use of SRH provides a near real-time diagnosis with high diagnostic accuracy and provides further developmental potential to improve personalized tumor surgery.
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