CarbDisMut: database on neutral and disease-causing mutations in human carbohydrate-binding proteins

Area of Science:

• Biochemistry
• Genomics
• Structural Biology

Background:

• Protein-carbohydrate interactions are crucial for cellular functions.
• Understanding mutations in carbohydrate-binding proteins is key to disease research.
• Existing databases lack specific resources for human carbohydrate-binding protein mutations.

Purpose of the Study:

• To develop CarbDisMut, a comprehensive database for disease-causing mutations in human carbohydrate-binding proteins.
• To integrate sequence and structural features of these mutations.
• To provide a freely accessible resource for researchers.

Main Methods:

• Database development using HTML, PHP, and JavaScript.
• Integration of mutation data from various sources.
• Inclusion of sequence and structural information for each mutation.

Main Results:

• CarbDisMut contains 1.17 million disease-associated mutations and 38,636 neutral mutations.
• The database covers 7,187 human carbohydrate-binding proteins.
• The website is accessible and supports major browsers.

Conclusions:

• CarbDisMut is a novel, integrated resource for studying disease-causing mutations in human carbohydrate-binding proteins.
• The database facilitates research into the molecular basis of diseases linked to these proteins.
• This resource will advance the understanding of protein-carbohydrate interactions in health and disease.