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Related Experiment Videos

Decrease in human growth hormone (HGH) levels during transsphenoidal surgery for acromegaly as a guide for prognosis.

S Yamada, Y Shishiba, M Kitano

    Endocrinologia Japonica
    |December 1, 1985
    PubMed
    Summary
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    Monitoring human growth hormone (HGH) levels during acromegaly surgery predicts successful outcomes. A rapid HGH assay helps surgeons assess tumor removal effectiveness in real-time.

    Area of Science:

    • Endocrinology
    • Neurosurgery
    • Surgical Oncology

    Background:

    • Acromegaly is a disorder caused by excessive human growth hormone (HGH) production, often due to pituitary tumors.
    • Transsphenoidal microsurgery is a primary treatment for acromegaly, but assessing surgical success intraoperatively can be challenging.

    Purpose of the Study:

    • To evaluate the clinical significance of intraoperative HGH dynamics during transsphenoidal microsurgery for acromegaly.
    • To assess the utility of a rapid radioimmunoassay (RIA) for real-time HGH monitoring during surgery.

    Main Methods:

    • Retrospective analysis of serial HGH levels during surgery and post-operative basal HGH in 15 acromegalic patients.
    • Development and validation of a rapid RIA for HGH measurement (results available in ~1 hour).

    Related Experiment Videos

  • Prospective application of the rapid RIA in 6 patients to correlate intraoperative and post-operative HGH levels.

    • Main Results:

    • HGH levels immediately post-resection <5 ng/ml or a >80% decrease during resection predicted normal post-operative HGH levels.
    • The rapid RIA demonstrated good correlation with conventional HGH assays.
    • Intraoperative HGH levels correlated well with post-operative outcomes in both retrospective and prospective analyses.

    Conclusions:

    • Intraoperative HGH levels and the extent of HGH decrease during resection are reliable indicators of surgical success in acromegaly.
    • The rapid RIA method is a valuable tool for quick intraoperative assessment of HGH levels, aiding surgical decision-making.