Polyethylene Glycol-Mediated Axonal Fusion Promotes Early Sensory Recovery after Digital Nerve Injury: A Randomized...

Area of Science:

• Neurosurgery
• Regenerative Medicine
• Biomaterials

Background:

• Peripheral nerve repair is challenged by Wallerian degeneration and slow nerve regrowth, leading to muscle atrophy.
• Polyethylene glycol (PEG) fusion of axonal membranes offers immediate action potential restoration.
• Preclinical studies showed PEG fusion promotes early functional recovery in nerve injuries.

Purpose of the Study:

• To evaluate the efficacy of PEG fusion compared to standard neurorrhaphy in a randomized clinical trial.
• To assess functional outcomes and quality of life following digital nerve repair.

Main Methods:

• First randomized clinical trial comparing PEG fusion and standard neurorrhaphy for digital nerve transections.
• Participants assessed at 2 weeks, 1 month, and 3 months postoperatively.
• Outcomes measured by Medical Research Council Classification (MRCC) for sensory recovery and Michigan Hand Outcomes Questionnaire.

Main Results:

• PEG-fused nerves showed significantly higher MRCC scores at 2 weeks and 1 month.
• PEG cohort reported significantly higher quality of life scores at 2 weeks and 1 month.
• No adverse events related to PEG were reported.

Conclusions:

• PEG fusion significantly enhances early sensory recovery in digital nerve repair.
• PEG fusion improves patient-reported well-being and quality of life.
• PEG fusion represents a safe and effective method for peripheral nerve repair.