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Updated: Jul 4, 2025

Prospecting Microbial Strains for Bioremediation and Probiotics Development for Metaorganism Research and Preservation
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Overview on biotics development.

Anne-Emmanuelle Roux1, Philippe Langella1, Rebeca Martin1

  • 1Paris-Saclay University, INRAE, AgroParisTech, Micalis Institute, 78350 Jouy-en-Josas, France.

Current Opinion in Biotechnology
|February 9, 2024
PubMed
Summary

Probiotics, including next-generation live biotherapeutics, offer promising treatments for diseases like Crohn's. This review explores probiotics, synbiotics, and postbiotics for gut health and therapeutic applications.

Area of Science:

  • Microbiology
  • Gastroenterology
  • Pharmacology

Background:

  • Probiotics have a long history of use, with recent technological advances driving significant growth in the field of gut microbiota and biotics.
  • The gut microbiota's role in health and disease is increasingly understood, leading to novel applications for probiotic interventions.

Purpose of the Study:

  • To review the applications of traditional probiotics.
  • To discuss the emergence and potential of next-generation probiotics as live biotherapeutics.
  • To explore the therapeutic promise of probiotics, synbiotics, and postbiotics for various diseases, including inflammatory bowel diseases.

Main Methods:

  • Literature review of traditional and next-generation probiotics.
  • Discussion of synbiotics (probiotics with prebiotics) and their combined effects.

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  • Exploration of the benefits and applications of postbiotics.

    • Main Results:

    • Traditional probiotics continue to be relevant, with new technological insights enhancing their application.
    • Next-generation probiotics show potential as live biotherapeutics for disease prevention and treatment.
    • Combinations like synbiotics and consortia of probiotic strains may offer enhanced therapeutic effects.

    Conclusions:

    • Probiotics, synbiotics, and postbiotics represent a growing area of research with significant therapeutic potential.
    • Novel probiotic strategies hold promise for managing inflammatory bowel diseases such as Crohn's disease and ulcerative colitis.
    • Further research into next-generation probiotics and postbiotics could lead to advanced treatment options for numerous health conditions.