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Updated: Jun 29, 2026

Transplantation of Pancreatic Islets Into the Kidney Capsule of Diabetic Mice
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Published on: October 31, 2007

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Hypoimmune islets achieve insulin independence after allogeneic transplantation in a fully immunocompetent non-human

Xiaomeng Hu1, Kathy White1, Chi Young1

  • 1Sana Biotechnology, Inc., 1 Tower Place, South San Francisco, CA 94080, USA.

Cell Stem Cell
|February 9, 2024
PubMed

Allogeneic transplantation of pancreatic islets for patients with difficult-to-control diabetes mellitus is severely hampered by the requirement for continuous immunosuppression and its associated morbidity. We report that allogeneic transplantation of genetically engineered (B2M-/-, CIITA-/-, CD47+), primary, hypoimmune, pseudo-islets (p-islets) results in their engraftment into a fully immunocompetent, diabetic non-human primate wherein they provide stable endocrine function and enable insulin independence without inducing any detectable immune response in the absence of immunosuppression. Hypoimmune primary p-islets may provide a curative cell therapy for type 1 diabetes mellitus.

Keywords:
hypoimmuneimmune evasive

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