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Related Concept Videos

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  3. Human Papillomavirus Genotypes And Risk Of Persistence And Progression In Women Undergoing Active Surveillance For Cervical Intraepithelial Neoplasia Grade 2.
  1. Home
  3. Human Papillomavirus Genotypes And Risk Of Persistence And Progression In Women Undergoing Active Surveillance For Cervical Intraepithelial Neoplasia Grade 2.

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Human papillomavirus genotypes and risk of persistence and progression in women undergoing active surveillance for

Rikke Kamp Damgaard1, David Jenkins2, Mark H Stoler3

  • 1Department of Clinical Medicine, Faculty of Health, Aarhus University, Aarhus, Denmark; Department of Obstetrics and Gynecology, Gødstrup Hospital, Herning, Denmark; NIDO, Center for Research and Education, Gødstrup Hospital, Herning, Denmark.

American Journal of Obstetrics and Gynecology
|February 9, 2024

View abstract on PubMed

Summary
This summary is machine-generated.
Keywords:
cervical cancer preventioncervical intraepithelial neoplasia grade 2clinical managementhuman papillomavirus genotypingrisk assessment

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Human papillomavirus (HPV) type 16 is linked to a higher risk of cervical intraepithelial neoplasia grade 2 persistence or progression. HPV-16 positive women with high-grade cytology require careful monitoring or early treatment.

Area of Science:

  • Gynecology
  • Oncology
  • Virology

Background:

  • Active surveillance is an alternative to excisional treatment for cervical intraepithelial neoplasia grade 2 in young women.
  • Excisional treatment carries risks, including preterm birth.
  • Identifying women at high risk for persistence/progression is crucial for timely intervention.

Purpose of the Study:

  • To investigate human papillomavirus (HPV) type-specific persistence/progression rates.
  • To identify biomarkers for predicting persistence/progression in women with cervical intraepithelial neoplasia grade 2 under active surveillance.

Main Methods:

  • Historical cohort study of 455 women aged 23-40 with cervical intraepithelial neoplasia grade 2.
  • HPV genotyping performed on archived tissue samples.
  • Persistence/progression defined by subsequent cervical intraepithelial neoplasia grade ≥2 diagnoses.

    • Main Results:

    • HPV-16 positivity was associated with a significantly higher risk of persistence/progression (RR 1.64).
    • The highest risk was observed in HPV-16 positive women with high-grade index cytology (RR 1.29).
    • Age was not a significant factor in persistence/progression risk.

    Conclusions:

    • HPV-16 positivity is a key indicator for increased risk of cervical intraepithelial neoplasia grade 2 persistence/progression.
    • High-grade cytology in HPV-16 positive women warrants consideration for early excisional treatment.