Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Confocal Fluorescence Microscopy01:16

Confocal Fluorescence Microscopy

13.3K
Confocal microscopy is an advanced microscopic technique. The prime advantage of the confocal microscope over other microscopy techniques is its ability to block the out-of-focus light from the illuminated samples using pinholes. It is widely used with fluorescence optics to obtain high-resolution, sharp contrast images. Unlike optical microscopes, confocal microscopes use a focused beam of light laser to scan the entire sample surface at different z-planes. These microscopes are, therefore,...
13.3K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

7.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Association between Advanced Lung Cancer Inflammation Index and mortality in US adults with obstructive sleep apnea.

Medicine·2026
Same author

A meta-analysis of the effects of Baduanjin training on the human body temperature based on infrared thermography technology.

Medicine·2026
Same author

Cell-autonomous co-stimulatory function of membrane-bound CD100 promotes activation and differentiation of HBcAg-specific CD8<sup>+</sup> T cells.

Frontiers in immunology·2026
Same author

Ag-CuO Nanozymes Superior to Commercial Silver-Based Dressings: Synergistic Antibacterial Therapy via PTS-Mediated Starvation and Cuproptosis-Like Death.

Research (Washington, D.C.)·2026
Same author

Early supplemental parenteral nutrition and risk of subsequent enteroatmospheric fistula in high-risk open abdomen patients with persistent enteral nutrition intolerance: a landmark propensity score-matched cohort study.

Frontiers in medicine·2026
Same author

Association between phenotypic age acceleration and mortality in patients with chronic obstructive pulmonary disease.

Respiratory medicine·2026

Related Experiment Video

Updated: Jul 4, 2025

LED-Based In Vitro Screening for Assessing Photoactivable Molecules in Bacterial Photodynamic Inactivation
05:13

LED-Based In Vitro Screening for Assessing Photoactivable Molecules in Bacterial Photodynamic Inactivation

Published on: January 24, 2025

316

Type I photodynamic antimicrobial therapy: Principles, progress, and future perspectives.

Jingai Jiang1, Xinyi Lv1, Huijuan Cheng1

  • 1Key Laboratory of Flexible Electronics (KLOFE) and Institute of Advanced Materials (IAM), School of Physical and Mathematical Sciences, Nanjing Tech University (NanjingTech), Nanjing 211816, China.

Acta Biomaterialia
|February 9, 2024
PubMed
Summary

Type I photodynamic therapy (PDT) offers a promising, oxygen-independent strategy against drug-resistant bacteria and biofilms. This approach overcomes limitations of traditional antibiotics and type II PDT, showing potential for treating challenging infections.

Keywords:
Bacterial infectionsPhotodynamic therapyType-I photosensitizer

More Related Videos

Rose Bengal-Mediated Photodynamic Therapy to Inhibit Candida albicans
04:48

Rose Bengal-Mediated Photodynamic Therapy to Inhibit Candida albicans

Published on: March 24, 2022

3.2K
An In-House-Built and Light-Emitting-Diode-Based Photodynamic Therapy Device for Enhancing Verteporfin Cytotoxicity in a 2D Cell Culture Model
11:04

An In-House-Built and Light-Emitting-Diode-Based Photodynamic Therapy Device for Enhancing Verteporfin Cytotoxicity in a 2D Cell Culture Model

Published on: January 13, 2023

3.0K

Related Experiment Videos

Last Updated: Jul 4, 2025

LED-Based In Vitro Screening for Assessing Photoactivable Molecules in Bacterial Photodynamic Inactivation
05:13

LED-Based In Vitro Screening for Assessing Photoactivable Molecules in Bacterial Photodynamic Inactivation

Published on: January 24, 2025

316
Rose Bengal-Mediated Photodynamic Therapy to Inhibit Candida albicans
04:48

Rose Bengal-Mediated Photodynamic Therapy to Inhibit Candida albicans

Published on: March 24, 2022

3.2K
An In-House-Built and Light-Emitting-Diode-Based Photodynamic Therapy Device for Enhancing Verteporfin Cytotoxicity in a 2D Cell Culture Model
11:04

An In-House-Built and Light-Emitting-Diode-Based Photodynamic Therapy Device for Enhancing Verteporfin Cytotoxicity in a 2D Cell Culture Model

Published on: January 13, 2023

3.0K

Area of Science:

  • Photodynamic Therapy
  • Antimicrobial Resistance
  • Biofilm Infections

Background:

  • Antibiotic resistance necessitates novel therapeutic strategies.
  • Photodynamic therapy (PDT) is a promising alternative due to its low adverse effects and lack of resistance development.
  • Bacterial biofilms create hypoxic environments, challenging oxygen-dependent (Type II) PDT.

Purpose of the Study:

  • To review the principles and mechanisms of Type I photodynamic therapy (PDT).
  • To explore the application of Type I PDT in combating bacterial infections, particularly biofilms.
  • To discuss the limitations and future directions of Type I photosensitizers.

Main Methods:

  • Detailed introduction to the fundamental principles of Type I PDT, including physicochemical properties and reactive oxygen species (ROS) generation.
  • Exploration of antimicrobial mechanisms employed by Type I PDT.
  • Summary of recent applications of Type I PDT in antimicrobial treatment.

Main Results:

  • Type I PDT is not constrained by oxygen concentration, offering an advantage over Type II PDT in hypoxic environments.
  • Type I PDT effectively eliminates drug-resistant bacteria and biofilms.
  • Recent studies demonstrate the potential of Type I PDT in various antimicrobial applications.

Conclusions:

  • Type I PDT is a potent strategy for treating bacterial infections, especially those involving biofilms.
  • Its non-oxygen-dependent nature makes it superior to Type II PDT in hypoxic conditions.
  • Further development of Type I photosensitizers is crucial for overcoming biofilm barriers and enhancing treatment efficacy.