Related Experiment Video
Updated: Jul 4, 2025

09:51
Enhanced Genome Editing with Cas9 Ribonucleoprotein in Diverse Cells and Organisms
Published on: May 25, 2018
33.9K
Clocks at sea: the genome-editing tide is rising
Erica R Kwiatkowski1, Joshua J C Rosenthal2, Patrick Emery1
1University of Massachusetts Chan Medical School, Department of Neurobiology, Worcester, MA 01605, USA.
Trends in Genetics : TIG
|February 9, 2024
Summary
Marine animals use biological clocks to adapt to daily, seasonal, tidal, and lunar cycles. New research explores the molecular basis of these crucial circatidal and circalunar clocks.
Area of Science:
- Marine biology
- Chronobiology
- Molecular mechanisms
Background:
- Coastal environments present complex temporal challenges, including solar, seasonal, tidal, and lunar cycles.
- Marine species exhibit remarkable adaptability, utilizing biological clocks to anticipate environmental cues for survival and reproduction.
- Understanding the molecular underpinnings of circatidal (tide-related) and circalunar (moon-related) biological clocks is currently limited.
Purpose of the Study:
- To investigate the molecular mechanisms governing circatidal and circalunar biological clocks in marine organisms.
- To highlight the transformative potential of recent advances in genome engineering and model organism development for marine chronobiology research.
Main Methods:
- Leveraging advances in genome engineering techniques.
- Utilizing genetically tractable marine model organisms for experimental studies.
- Investigating molecular pathways associated with biological timekeeping in response to environmental cycles.
Main Results:
- (This section would typically detail specific findings, but the abstract focuses on the potential and future direction.)
- The study sets the stage for future discoveries by establishing a framework for molecular investigation.
- Highlights the potential for new insights into how marine life synchronizes with environmental rhythms.
Conclusions:
- Recent technological advancements are poised to revolutionize the study of marine biological clocks.
- A deeper understanding of circatidal and circalunar clocks is emerging, promising novel insights into marine adaptation.
- This research opens a new era in marine chronobiology, focusing on molecular mechanisms of timekeeping.
Related Concept Videos
CRISPR
51.0K
Genome editing technologies allow scientists to modify an organism’s DNA via the addition, removal, or rearrangement of genetic material at specific genomic locations. These types of techniques could potentially be used to cure genetic disorders such as hemophilia and sickle cell anemia. One popular and widely used DNA-editing research tool that could lead to safe and effective cures for genetic disorders is the CRISPR-Cas9 system. CRISPR-Cas9 stands for Clustered Regularly Interspaced...
51.0K
RNA Editing
9.0K
RNA editing is a post-transcriptional modification where a precursor mRNA (pre-mRNA) nucleotide sequence is changed by base insertion, deletion, or modification. The extent of RNA editing varies from a few hundred bases, in mitochondrial DNA of trypanosomes, to a just single base, in nuclear genes of mammals. Even a single base change in the pre-mRNA can convert a codon for one amino acid into the codon for another amino acid or a stop codon. This type of re-coding can significantly affect the...
9.0K
Next-generation Sequencing
88.8K
The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features....
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features....
88.8K
Sanger Sequencing
754.3K
DNA sequencing is a fundamental technique that is routinely used in the biological sciences. This method can be applied to a range of questions at different scales - from the sequencing of a cloned DNA fragment or the study of a mutation in a gene up to whole-genome sequencing. However, despite the widespread use of sequencing today, it was not until 1977 that Fredrick Sanger and his collaborators developed the chain-termination method to decode DNA sequences. It relies on the separation of a...
754.3K
CRISPR and crRNAs
17.0K
Bacteria and archaea are susceptible to viral infections just like eukaryotes; therefore, they have developed a unique adaptive immune system to protect themselves. Clustered regularly interspaced short palindromic repeats and CRISPR-associated proteins (CRISPR-Cas) are present in more than 45% of known bacteria and 90% of known archaea.
The CRISPR-Cas system stores a copy of foreign DNA in the host genome and uses it to identify the foreign DNA upon reinfection. CRISPR-Cas has three different...
The CRISPR-Cas system stores a copy of foreign DNA in the host genome and uses it to identify the foreign DNA upon reinfection. CRISPR-Cas has three different...
17.0K
Animal Mitochondrial Genetics
7.6K
Among all the organelles in an animal cell, only mitochondria have their own independent genomes. Animal mitochondrial DNA is a double-stranded, closed-circular molecule with around 20,000 base pairs. Mitochondrial DNA is unique in that one of its two strands, the heavy, or H, -strand is guanine rich, whereas the complementary strand is cytosine rich and called the light, or L, -strand. Compared to nuclear DNA, mitochondrial DNA has a very low percentage of non-coding regions and is marked by...
7.6K

