Impact of triglyceride-glucose index on intracoronary thrombus burden in ST-elevation myocardial infarction patients...

Area of Science:

• Cardiology
• Biochemistry
• Medical Diagnostics

Background:

• ST-elevation myocardial infarction (STEMI) is a critical cardiovascular condition.
• Intracoronary thrombus burden is a key factor in STEMI prognosis.
• Percutaneous coronary intervention (PCI) is a primary treatment for STEMI.

Purpose of the Study:

• To investigate the relationship between the triglyceride glucose (TyG) index and intracoronary thrombus burden in STEMI patients.
• To determine if the TyG index can predict large thrombus burden (LTB) in STEMI patients undergoing primary PCI.

Main Methods:

• A total of 468 STEMI patients undergoing primary PCI were analyzed.
• The triglyceride glucose (TyG) index was calculated using fasting triglyceride and glucose levels.
• Patients were categorized into small thrombus burden (STB) and large thrombus burden (LTB) groups based on TIMI thrombus grade.

Main Results:

• The TyG index was significantly higher in patients with LTB compared to those with STB (p=0.002).
• Multivariate analysis identified the TyG index as an independent predictor of LTB in STEMI patients (OR: 1.470, p=0.012).
• A TyG index cut-off of 8.87 showed a higher frequency of LTB in the high TyG index group (p=0.003).

Conclusions:

• The TyG index, a marker of insulin resistance, is an independent predictor of LTB in STEMI patients.
• The TyG index can serve as a valuable indicator of increased intracoronary thrombus burden in STEMI patients undergoing primary PCI.