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Related Concept Videos

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution01:25

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...

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Related Experiment Video

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Equity in bariatric surgery use: a cohort study.

Victoria Gershuni1, Elizabeth Wall-Wieler2, Yuki Liu3

  • 1Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery
|February 9, 2024
PubMed
Summary

Metabolic and bariatric surgery (MBS) is effective for obesity, but access is unequal. This study reveals significant disparities in MBS rates across demographics, health factors, and geography, highlighting the need to reduce access barriers.

Keywords:
Bariatric surgeryCohort studyHealth equity

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Area of Science:

  • Bariatric Surgery
  • Obesity Treatment
  • Health Equity

Background:

  • Metabolic and bariatric surgery (MBS) is the most effective obesity treatment.
  • Equitable access to MBS remains a significant challenge.

Purpose of the Study:

  • To determine MBS rates among eligible US adults with obesity.
  • To analyze disparities by demographics, health characteristics, and geography.
  • To identify populations needing resources to overcome access barriers.

Main Methods:

  • Retrospective analysis of a US employer-based claims database (Merative™).
  • Examined MBS rates across demographics (age, sex, region, etc.) and health characteristics (comorbidities, costs, admissions).
  • Analyzed rates for Class 2 (BMI 35-39.9) and Class 3 (BMI 40+) obesity separately.

Main Results:

  • Overall MBS rate was 6.4% (49,371/777,565 eligible adults).
  • Rates varied significantly: 3.2% (Class 2) vs. 8.3% (Class 3) overall; geographically from 0% to 15.3%.
  • Substantial differences observed across demographic and health profiles, indicating inequitable access.

Conclusions:

  • MBS utilization among eligible adults with obesity shows significant variation.
  • These disparities underscore inequities in access to this crucial treatment.
  • Policy interventions are needed to reduce barriers and improve access to MBS for obesity.