Base editing effectively prevents early-onset severe cardiomyopathy in Mybpc3 mutant mice

Shuo Wu¹, Ping Yang¹, Zilong Geng¹+11

• ¹Key Laboratory of Systems Biomedicine, Shanghai Center for Systems Biomedicine, Department of Cardiovascular Surgery, Shanghai Chest Hospital, Engineering Research Center of Techniques and Instruments for Diagnosis and Treatment of Congenital Heart Disease, Institute of Developmental and Regenerative Medicine, Xin Hua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.+6