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Related Concept Videos

Bacterial Flora of the Large Intestine01:29

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The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
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Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
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Updated: Jul 4, 2025

Co-culture of Living Microbiome with Microengineered Human Intestinal Villi in a Gut-on-a-Chip Microfluidic Device
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The Human Gut Microbiota: A Dynamic Biologic Factory.

Alireza Minagar1, Rabih Jabbour2

  • 1Department of Biotechnology (Bioinformatics), University of Maryland Global Campus, Adelphi, MD, USA.

Advances in Biochemical Engineering/Biotechnology
|February 10, 2024
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Summary
This summary is machine-generated.

The human gut microbiota, comprising trillions of microorganisms, plays a vital role in host health and disease. Research explores its collective genomic content and symbiotic functions in metabolism, immunity, and disease development.

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Area of Science:

  • Microbiology
  • Human Physiology
  • Genomics

Background:

  • The human body hosts trillions of microorganisms, forming the microbiome.
  • The gut microbiota, primarily bacteria, resides in the gastrointestinal tract.
  • Microbiota genes significantly outnumber host genes, highlighting their functional importance.

Purpose of the Study:

  • To explore the biological features of gut microbiota.
  • To understand its physiology as a biological factory.
  • To elucidate its impact on host health and disease.

Main Methods:

  • Review of scientific literature on gut microbiota.
  • Analysis of the symbiotic relationship between microorganisms and the human host.
  • Investigation of the collective genomic content (microbiome) and its functions.

Main Results:

  • Gut microbiota influences host metabolic, physiological, and immune activities.
  • Microbiota composition is dynamic and adapts to host-specific factors.
  • Research increasingly links gut microbiome to diseases like colorectal cancer and immune disorders.

Conclusions:

  • The gut microbiota is a complex ecosystem with profound impacts on human health.
  • Understanding its functions is crucial for developing novel therapeutic strategies.
  • Further research is needed to fully unravel the gut microbiome's role in health and disease.