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Methods for Detecting Cough and Airway Inflammation in Mice
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Methods for Detecting Cough and Airway Inflammation in Mice

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Endotypes of Paediatric Cough-Do They Exist and Finding New Techniques to Improve Clinical Outcomes

Hannah E O'Farrell1,2, Hing Cheong Kok1,3, Suhani Goel2

  • 1NHMRC Centre for Research Excellence in Paediatric Bronchiectasis (AusBREATHE), Child and Maternal Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, NT 0810, Australia.

Journal of Clinical Medicine
|February 10, 2024
PubMed

Insights

Characterizing chronic cough in children through endotyping is crucial. This approach aids in precise diagnosis, targeted treatments, and understanding underlying lung disease mechanisms for better outcomes.

Area of Science:

  • Pediatric Pulmonology
  • Translational Medicine
  • Biomarker Discovery

Background:

  • Chronic cough is a prevalent symptom in pediatric lung diseases, often presenting with diverse phenotypes.
  • Current diagnostic approaches lack precision due to the heterogeneity of chronic cough.
  • Understanding the underlying pathobiology is essential for developing effective treatments.

Purpose of the Study:

  • To review recent advances in endotype discoveries for airway diseases in children.
  • To outline multi-omic strategies for defining chronic cough endotypes.
  • To discuss potential biospecimens for endotype and biomarker identification.

Main Methods:

  • Literature review focusing on pediatric airway diseases and chronic cough.
  • Exploration of multi-omic technologies (genomics, transcriptomics, proteomics, etc.).
  • Analysis of studies identifying potential biomarkers and biospecimens.

Main Results:

  • Phenotypic heterogeneity necessitates endotyping for accurate diagnosis and treatment.
  • Multi-omic approaches are vital for defining distinct endotypes.
  • Various biospecimens hold promise for identifying novel biomarkers.

Conclusions:

  • Endotyping chronic cough in children offers a pathway to personalized medicine.
  • Improved clinical outcomes are anticipated through precise diagnosis and targeted therapies.
  • Further research into multi-omic data and biospecimens is warranted.

Keywords:
biomarkerschildrencoughendotypesmulti-omicsreview

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