Related Experiment Video

Updated: Jul 4, 2025

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development
08:50

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

Published on: June 24, 2020

3.8K

The Association between Term Chorioamnionitis during Labor and Long-Term Infectious Morbidity of the Offspring

Noa Efrat Davidi1, Gil Gutvirtz1,2, Eyal Sheiner1,2

  • 1Faculty of Health Sciences, Joyce and Irving Goldman Medical School, Ben Gurion University of the Negev, Beer-Sheva 84105, Israel.

Journal of Clinical Medicine
|February 10, 2024
PubMed

Insights

Term chorioamnionitis during labor does not increase a child's risk for long-term infectious diseases. This study found no significant difference in pediatric infectious morbidity for offspring born to mothers with or without chorioamnionitis.

Area of Science:

  • Obstetrics and Gynecology
  • Pediatric Infectious Diseases
  • Immunology

Background:

  • Chorioamnionitis during labor may alter fetal immune development, potentially increasing susceptibility to infections.
  • The long-term impact of intra-amniotic infection on offspring's future infectious disease risk is not fully understood.

Purpose of the Study:

  • To evaluate the association between term chorioamnionitis during labor and long-term pediatric infectious morbidity.
  • To determine if exposure to chorioamnionitis in utero increases a child's susceptibility to infections up to age 18.

Main Methods:

  • Population-based cohort analysis of term singleton deliveries (1991-2021).
  • Comparison of offspring hospitalized for infectious morbidity up to age 18, with and without maternal chorioamnionitis during labor.
  • Statistical analysis using Kaplan-Meier curves and Cox regression to control for confounders.

Main Results:

  • A total of 331,598 deliveries were analyzed; 988 (0.3%) involved maternal chorioamnionitis.
  • No significant differences in infectious morbidity rates were observed between the groups.
  • Multivariable analysis confirmed chorioamnionitis during labor was not a risk factor for long-term pediatric infectious morbidity (HR 0.929, p=0.254).

Conclusions:

  • Term chorioamnionitis during labor is not associated with an increased risk of pediatric hospitalization for infections.
  • The intra-amniotic infectious/inflammatory state during labor does not appear to increase the susceptibility of term offspring to future infectious morbidity.

Keywords:
chorioamnionitisfollow-upinfectious morbiditylaborlong-termterm pregnancy

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