Advances in Multi-Modality Imaging in Hypertrophic Cardiomyopathy

Area of Science:

• Cardiology
• Medical Imaging

Background:

• Hypertrophic cardiomyopathy (HCM) involves abnormal myocardial growth, myofilament disarray, and hyper-contractility, leading to left ventricular hypertrophy and fibrosis.
• Genetic factors related to cardiomyocyte sarcomere structure and function are often implicated in HCM.

Purpose of the Study:

• To review the roles of various imaging modalities in the diagnosis, monitoring, and risk stratification of HCM.
• To discuss the strengths and limitations of electrocardiography, echocardiography, cardiac magnetic resonance (CMR), cardiac computed tomography (CT), and nuclear imaging in HCM management.

Main Methods:

• Review of current literature and guidelines, focusing on established and emerging imaging techniques for HCM.
• Analysis of multi-modality imaging approaches, including their combined use for personalized patient care.

Main Results:

• Each imaging modality (ECG, echocardiography, CMR, CT, nuclear imaging) offers unique insights into HCM.
• Combining imaging techniques can enhance diagnostic accuracy, risk stratification, and treatment planning for HCM patients.

Conclusions:

• Multi-modality imaging is essential for comprehensive HCM management, from diagnosis to risk assessment.
• Integrating various imaging modalities supports personalized patient care and advances research in HCM.