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Updated: Jul 4, 2025

Semi-Targeted Ultra-High-Performance Chromatography Coupled to Mass Spectrometry Analysis of Phenolic Metabolites in Plasma of Elderly Adults

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Mitigating Age-Related Cognitive Decline and Oxidative Status in Rats Treated with Catechin and Polyphenon-60.

Silvia Tejada^1,2,3, Fiorella Sarubbo^1,3, Manuel Jiménez-García^1,3

¹Laboratory of Neurophysiology, University of the Balearic Islands, 07122 Palma de Mallorca, Spain.

|February 10, 2024

Summary

Antioxidants like catechin and green tea extract (polyphenon-60) improved cognitive function and reduced oxidative stress in aged rats, slowing brain aging.

Keywords:

Barnes maze test antioxidant enzymes cognitive decline lipidic damage polyphenols

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Area of Science:

Neuroscience
Gerontology
Pharmacology

Background:

Aging involves oxidative stress and neuroinflammation, impacting brain function.
Phenolic compounds offer antioxidant and anti-inflammatory benefits, potentially slowing brain aging.

Purpose of the Study:

To evaluate the neuroprotective effects of catechin and polyphenon-60 in aged rats.
To assess their impact on visuo-spatial learning and frontal cortex oxidative status.

Main Methods:

Aged rats were treated daily with catechin or green tea extract (polyphenon-60) for 36 days.
Cognitive performance was measured using a visuo-spatial learning test.
Brain oxidative stress biomarkers and reactive oxygen species were analyzed.

Main Results:

Treated aged rats showed improved visuo-spatial learning compared to controls.
Antioxidant treatments partially restored brain antioxidant enzyme activities.
Reactive oxygen species and malondialdehyde levels were significantly reduced in the frontal cortex.

Conclusions:

Catechin and polyphenon-60 administration enhanced cognitive function in aged rats.
These compounds mitigated oxidative stress in the aging brain.
The findings suggest potential therapeutic benefits for slowing brain aging.