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Author Spotlight: Developing a Rat Model for Weight-Bearing Intervention to Investigate Osteonecrosis of the Femoral Head
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A Comprehensive Review of COVID-19-Infection- and Steroid-Treatment-Associated Bone Avascular Necrosis: A Multi-Study

Evangelos Sakellariou1, Evangelia Argyropoulou2, Panagiotis Karampinas1

  • 1Department of Orthopaedic Surgery, National & Kapodistrian University of Athens, KAT General Hospital, 14561 Athens, Greece.

Diagnostics (Basel, Switzerland)
|February 10, 2024
PubMed

Insights

Steroid therapy for COVID-19 may be linked to avascular necrosis (AVN) of the hip. However, treatment duration or dosage did not correlate with AVN development, necessitating further research.

Area of Science:

  • Orthopedics
  • Infectious Diseases
  • Pharmacology

Background:

  • The COVID-19 pandemic has strained healthcare systems globally.
  • Emerging evidence suggests a link between COVID-19 treatments, particularly steroid therapy, and avascular necrosis (AVN) of the hip.
  • Understanding this relationship is vital for managing patient care and potential complications.

Purpose of the Study:

  • To review recent studies and case reports on the association between COVID-19, corticosteroid therapy, and hip AVN.
  • To provide a comprehensive overview of the current evidence.
  • To inform healthcare professionals on treatment decisions and complication mitigation.

Main Methods:

  • A systematic review was conducted following PRISMA guidelines.
  • Literature search was performed up to September 1, 2023.
  • Full texts of 23 relevant articles were independently reviewed.

Main Results:

  • A noteworthy association exists between steroid therapy for COVID-19 and the development of hip AVN.
  • No clear relationship was found between treatment duration, cumulative dosage, or maximum daily dosage and the presence of AVN.
  • The review highlights a significant concern regarding steroid-induced AVN in COVID-19 patients.

Conclusions:

  • The association between steroid therapy for COVID-19 and hip AVN is a significant concern.
  • Further research with larger cohorts and long-term follow-up is required.
  • Optimal management strategies for hip AVN in the context of COVID-19 and steroid therapy need further investigation.
Abstract

Keywords:
AVNCOVID-19bone avascular necrosiship painosteonecrosissteroids

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