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Effect of Regular Training on Platelet Function in Untrained Thoroughbreds.

Arianna Miglio1, Emanuela Falcinelli2, Katia Cappelli1

  • 1Department of Veterinary Medicine, University of Perugia, Via San Costanzo 4, 06126 Perugia, Italy.

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Training young Thoroughbreds increases platelet activation and modifies hemostasis during the initial sprint exercise program. However, regular physical training can mitigate these acute effects on platelet function.

Keywords:
Thoroughbred racehorsecoagulationequinefirst long-term trainingplatelet aggregation

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Area of Science:

  • Equine physiology
  • Exercise science
  • Hematology

Background:

  • Training significantly impacts blood coagulation and hemostasis in horses.
  • Previous studies on exercise-induced hemostatic changes in horses are inconclusive.

Purpose of the Study:

  • To investigate platelet activation and primary hemostasis modifications in young, never-trained Thoroughbreds during their first incremental training period.
  • To enhance understanding of exercise physiology in equine athletes.

Main Methods:

  • Twenty-nine 2-year-old Thoroughbreds underwent a 4-month incremental sprint exercise training program.
  • Platelet aggregation, platelet function (PFA-100®), plasma nitrite-nitrate (NOx) concentrations, and platelet gene expression were analyzed monthly.
  • Data were compared across five time points during the training period.

Main Results:

  • Platelet aggregation increased significantly, and closure time on collagen/ADP cartridges shortened after 30 days of training, indicating increased platelet activity.
  • Plasma NOx concentrations also significantly increased after 30 days.
  • These modifications tended to return to baseline by 90 days.

Conclusions:

  • The initial phase of long-term training appears to induce temporary platelet hyperactivity in untrained Thoroughbreds.
  • Regular physical training may reduce the negative effects of acute exercise on platelet activation and hemostasis.