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High-throughput Detection Method for Influenza Virus
Published on: February 4, 2012
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Bovine Parainfluenza-3 Virus Detection Methods and Prevalence in Cattle: A Systematic Review and Meta-Analysis
Gebremeskel Mamu Werid1, Thien D Van1, Darren Miller1
1Davies Livestock Research Centre, School of Animal & Veterinary Sciences, University of Adelaide, Roseworthy Campus, Roseworthy, SA 5371, Australia.
Animals : an Open Access Journal From MDPI
|February 10, 2024
Summary
Bovine parainfluenza-3 virus (BPI3V) significantly impacts cattle respiratory health. Its global prevalence varies widely depending on detection methods, highlighting the need for focused research on this key BRDC pathogen.
Area of Science:
- Veterinary Virology
- Epidemiology
- Animal Health
Background:
- Bovine parainfluenza-3 virus (BPI3V) is a significant respiratory pathogen in cattle.
- It contributes to the bovine respiratory disease complex (BRDC), impacting herd health and productivity.
- Current understanding of BPI3V prevalence, particularly within the context of BRDC, is fragmented.
Purpose of the Study:
- To systematically review and meta-analyze the global prevalence of BPI3V in cattle.
- To investigate how different detection methods influence observed BPI3V prevalence.
- To identify potential risk factors associated with BPI3V infection in cattle.
Main Methods:
- Systematic literature search and meta-analysis of 71 selected studies from 32 countries.
- Analysis of BPI3V prevalence data based on various detection methods (antibody, antigen, nucleic acid, virus isolation).
- Exploration of potential influencing factors including coinfections, farm size, and clinical signs.
Main Results:
- Global BPI3V prevalence varied significantly by detection method.
- Antibody detection showed the highest prevalence (0.64 general population, 0.75 in BRDC cases).
- Nucleic acid and virus isolation methods reported lower prevalence rates (0.05-0.10 and 0.04-0.05, respectively).
Conclusions:
- Detection methodology critically impacts the reported prevalence of BPI3V in cattle.
- BPI3V is an important contributor to BRDC, but its specific role may be underestimated.
- Further dedicated research on BPI3V is essential for targeted disease control strategies.
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