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Updated: Jul 3, 2025
12:06
Metabolic Glycoengineering of Sialic Acid Using N-acyl-modified Mannosamines
Published on: November 25, 2017
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Mannose Ligands for Mannose Receptor Targeting
Marija Paurević1, Martina Šrajer Gajdošik1, Rosana Ribić2
1Department of Chemistry, Josip Juraj Strossmayer University of Osijek, Cara Hadrijana 8/A, HR-31000 Osijek, Croatia.
International Journal of Molecular Sciences
|February 10, 2024
Summary
Mannose receptor (MR) targeted drug delivery utilizes mannosylated formulations for efficient delivery to immune cells. This approach shows promise for treating cancer and infectious diseases by leveraging MR
Area of Science:
- Immunology
- Drug Delivery
- Biochemistry
Background:
- The mannose receptor (MR, CD 206) is an endocytic receptor on macrophages and dendritic cells.
- MR plays a key role in endocytosis, antigen processing, and presentation.
- MR's carbohydrate recognition domains (CRDs) bind strongly to oligosaccharides.
Purpose of the Study:
- To review the synthesis and application of mannosylated bioactive formulations for MR-mediated delivery.
- To highlight recent findings on structural features for MR ligand binding.
- To discuss MR-targeted delivery for cancer and infectious disease treatments.
Main Methods:
- Review of recent literature on mannosylated formulations and MR interactions.
- Analysis of synthesis strategies for mannose-containing ligands.
- Evaluation of therapeutic applications in cancer and infectious diseases.
Main Results:
- Multivalent mannose presentation on various templates (peptides, polymers, etc.) enables efficient MR-mediated delivery.
- Specific structural features of mannose ligands are crucial for successful MR binding.
- Mannosylated formulations show therapeutic potential for cancer and infectious diseases.
Conclusions:
- Mannosylated bioactive formulations are effective for MR-targeted delivery.
- Understanding ligand structure-binding relationships is key for optimizing delivery systems.
- MR-mediated delivery offers a promising strategy for treating various diseases.
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