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Updated: Jul 3, 2025

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Leucine Zipper Downregulated in Cancer-1 Interacts with Clathrin Adaptors to Control Epidermal Growth Factor Receptor

Hsien-Neng Huang1,2, Pin-Feng Hung3, Yai-Ping Chen3

  • 1Department of Pathology, National Taiwan University Hospital Hsin-Chu Branch, No. 25, Ln. 442, Section 1, Jingguo Road, North Dist., Hsinchu 300195, Taiwan.

International Journal of Molecular Sciences
|February 10, 2024
PubMed
Summary

Leucine zipper downregulated in cancer-1 (LDOC1) affects epidermal growth factor receptor (EGFR) internalization in non-small cell lung cancer (NSCLC). LDOC1 depletion reduces sensitivity to EGFR-tyrosine kinase inhibitors (TKIs), suggesting LDOC1 as a prognostic biomarker.

Keywords:
Leucine zipper downregulated in cancer-1 (LDOC1)clathrin adaptor proteinepidermal growth factor receptor (EGFR)gefitinibnon-small cell lung cancer (NSCLC)

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