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Unraveling the Role of Ras Homolog Enriched in Brain (Rheb1 and Rheb2): Bridging Neuronal Dynamics and Cancer
Mostafizur Rahman1, Tuan Minh Nguyen1, Gi Jeong Lee1
1College of Pharmacy, Dongguk University, Seoul 04620, Republic of Korea.
International Journal of Molecular Sciences
|February 10, 2024
Summary
Ras homolog enriched in brain (Rheb1) proteins regulate neuronal activity and are implicated in cancer progression. This review explores Rheb1
Area of Science:
- Molecular Biology
- Oncology
- Neuroscience
Background:
- Ras homolog enriched in brain (Rheb1 and Rheb2) are small GTPases vital for neuronal activity.
- Rheb proteins are increasingly recognized for their role in cancer development, especially breast cancer.
- The specific functions of Rheb2 remain less understood compared to Rheb1.
Purpose of the Study:
- To investigate the complex relationship between Rheb1 functions in neurons and its role in cancer.
- To elucidate Rheb1's involvement in key cancer hallmarks: proliferation, apoptosis resistance, migration, invasion, metastasis, and inflammation.
- To consolidate current knowledge on Rheb1's impact on cancer and its potential as a therapeutic target.
Main Methods:
- Literature review consolidating existing research on Rheb1 and Rheb2.
- Analysis of Rheb1's involvement in cellular processes relevant to cancer.
- Exploration of the mTOR pathway's connection to Rheb1 in cancer.
Main Results:
- Rheb1 influences multiple cancer hallmarks, including proliferation and metastasis.
- The mTOR pathway is a key mediator of Rheb1's oncogenic functions.
- Significant gaps exist in understanding the precise molecular mechanisms of Rheb1 in cancer.
Conclusions:
- Rheb1 is a significant factor in cancer development and progression.
- Targeting Rheb1, potentially through inhibitors, presents a promising therapeutic strategy for cancer.
- Further research is needed to fully understand Rheb1/Rheb2 interplay and develop effective treatments.
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