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Related Concept Videos

MicroRNAs01:22

MicroRNAs

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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
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De novo myogenesis, or the formation of muscle fibers, begins during the early embryonic stages. The skeletal muscle is formed from somites– blocks of embryonic cell layers. The somites are further divided into dermatomes, myotomes, sclerotomes, and syndetomes. Among these, the myotomes give rise to muscle fibers.
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In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge
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miRNAs in Heart Development and Disease.

Estefania Lozano-Velasco1, José Manuel Inácio2, Inês Sousa3

  • 1Cardiovascular Development Group, Department of Experimental Biology, University of Jaen, 23071 Jaen, Spain.

International Journal of Molecular Sciences
|February 10, 2024
PubMed
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MicroRNAs (miRNAs) are key regulators in cardiovascular diseases (CVD). Bioinformatics tools accelerate the discovery of miRNA roles and therapeutic targets for heart conditions.

Keywords:
bioinformatic toolscardiovascular diseasesheart developmentmiRNA

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Area of Science:

  • Biochemistry
  • Genetics
  • Cardiology

Background:

  • Cardiovascular diseases (CVD) represent a significant global health burden, necessitating novel therapeutic strategies.
  • MicroRNAs (miRNAs) are crucial post-transcriptional regulators involved in cardiac development, function, and pathology.
  • miRNAs hold potential as biomarkers and therapeutic targets for cardiovascular conditions.

Purpose of the Study:

  • To review the role of miRNAs in cardiac development and CVD.
  • To highlight the application of bioinformatics in miRNA research for cardiovascular medicine.
  • To discuss challenges and opportunities in the field.

Main Methods:

  • Literature review of miRNA functions in cardiovascular biology.
  • Analysis of bioinformatics tools for miRNA identification, target prediction, and expression profiling.
  • Synthesis of current knowledge on miRNA-based cardiovascular research.

Main Results:

  • miRNAs significantly influence cardiac development and are implicated in various CVDs.
  • Bioinformatic algorithms are essential for dissecting miRNA-mediated gene regulation and interactions in the heart.
  • The integration of miRNA research and bioinformatics offers promising avenues for CVD diagnosis and treatment.

Conclusions:

  • miRNAs are pivotal in cardiovascular health and disease, offering therapeutic potential.
  • Bioinformatics is indispensable for advancing our understanding of miRNA roles in cardiology.
  • Further research integrating miRNA biology and computational approaches is crucial for developing effective CVD interventions.