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Evaluation of Polymeric Gene Delivery Nanoparticles by Nanoparticle Tracking Analysis and High-throughput Flow Cytometry
Published on: March 1, 2013
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mRNA Delivery: Challenges and Advances through Polymeric Soft Nanoparticles
Samaneh Yousefi Adlsadabad1, John W Hanrahan2, Ashok Kakkar1
1Department of Chemistry, McGill University, 801 Sherbrooke St West, Montreal, QC H3A 0B8, Canada.
International Journal of Molecular Sciences
|February 10, 2024
Summary
Polymeric nanoparticles offer advanced delivery for messenger ribonucleic acid (mRNA) therapeutics, overcoming limitations of lipid nanocarriers. This review explores recent progress in polymeric architectures for mRNA delivery, aiming for clinical translation.
Area of Science:
- Biotechnology
- Materials Science
- Nanomedicine
Background:
- Messenger ribonucleic acid (mRNA) is crucial for genetic information transfer and therapeutic applications.
- Lipid nanocarriers have been successful for mRNA delivery, notably in SARS-CoV-2 vaccines.
- Limitations of lipid nanocarriers necessitate alternative delivery systems for mRNA therapeutics.
Purpose of the Study:
- To review recent advances in polymeric architectures for messenger ribonucleic acid (mRNA) delivery.
- To discuss the limitations and existing challenges of polymer-based mRNA delivery systems.
- To facilitate further research and clinical translation of polymeric mRNA formulations.
Main Methods:
- Review of recent scientific literature on polymeric nanoparticles for mRNA delivery.
- Analysis of synthetic strategies for tailoring macromolecule-based nanocarriers.
- Evaluation of parameters such as mRNA protection, loading efficacy, and targeted release.
Main Results:
- Polymer-based soft nanoparticles present a modular platform for mRNA delivery.
- Synthetic articulation allows for tailored nanocarrier properties for enhanced mRNA delivery.
- Recent developments show promise in overcoming limitations of existing mRNA delivery systems.
Conclusions:
- Polymeric architectures are emerging as promising alternatives to lipid nanocarriers for mRNA delivery.
- Further research and development are needed to address existing challenges for clinical translation.
- Optimized polymeric nanocarriers hold potential for diverse therapeutic interventions using mRNA.
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