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The Various Roles of PEDF in Cancer
Mitra Elmi1,2, Joshua H Dass1,3, Crispin R Dass1,2
1Curtin Medical School, Curtin University, Bentley, WA 6102, Australia.
Abstract:
Pigment epithelium-derived factor (PEDF) is a natural immunomodulator, anti-inflammatory, anti-angiogenic, anti-tumour growth and anti-metastasis factor, which can enhance tumour response to PEDF but can also conversely have pro-cancerous effects. Inflammation is a major cause of cancer, and it has been proven that PEDF has anti-inflammatory properties. PEDF's functional activity can be investigated through measuring metastatic and metabolic biomarkers that will be discussed in this review.
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