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NORAD-Regulated Signaling Pathways in Breast Cancer Progression

Ana Maria Capela1, Carlota Tavares-Marcos1, Hugo F Estima-Arede1

  • 1Department of Medical Sciences, Institute of Biomedicine-iBiMED, University of Aveiro, 3810-193 Aveiro, Portugal.

Cancers
|February 10, 2024
PubMed

Insights

Long non-coding RNA NORAD plays a complex role in breast cancer (BC) progression. Understanding NORAD

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • Long non-coding RNA activated by DNA damage (NORAD) is implicated in cancer progression.
  • NORAD exhibits contradictory roles as either an oncogene or tumor suppressor in breast cancer (BC).

Purpose of the Study:

  • To review NORAD's function across different BC subtypes.
  • To elucidate NORAD's impact on critical signaling pathways in BC.
  • To explore NORAD's potential in overcoming chemotherapy resistance.

Main Methods:

  • Literature review summarizing existing research on NORAD in BC.
  • Analysis of NORAD's interactions with PUM proteins (PUM1, PUM2) and other molecules.
  • Investigation of NORAD's influence on cellular processes like cell cycle and angiogenesis.

Main Results:

  • NORAD's binding to PUM proteins regulates cell cycle, angiogenesis, mitosis, DNA replication, transcription, and protein translation.
  • Emerging evidence highlights PUM-independent roles of NORAD through interactions with ncRNAs, mRNAs, and proteins.
  • NORAD's complex signaling network offers potential therapeutic targets.

Conclusions:

  • NORAD's multifaceted roles in BC necessitate further investigation.
  • Targeting NORAD-mediated pathways may offer novel strategies for BC treatment, particularly for overcoming chemotherapy resistance.
Keywords:
NORADbreast cancerchemotherapy resistancelncRNAspumilio

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