Jove
Visualize
Contact Us

Related Concept Videos

Cadherins in Tissue Organization01:19

Cadherins in Tissue Organization

3.0K
The cadherins are a superfamily of cell adhesion molecules comprising over 180 variants, with specific tissues expressing a particular combination of cadherin types. Cadherins generally exhibit homophilic binding; i.e., cadherins on one cell bind to cadherins of the same or closely related type on another cell. Thus, cells of the same type have a specific affinity to bind to each other and sort themselves into clusters to form tissues.
Cell Sorting During Development
Cell sorting plays an...
3.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A targetable opioid/cancer associated fibroblast axis drives extracellular matrix remodeling and tumor aggressiveness in pancreatic cancer.

bioRxiv : the preprint server for biology·2026
Same author

Alprazolam Reduces Inflammatory Cytokine Production in Pancreatic Cancer-Associated Fibroblasts.

Cancer research communications·2026
Same author

Multiomic characterisation of the clinical efficacy of guselkumab induction therapy in ulcerative colitis.

BMJ open gastroenterology·2026
Same author

Deuterium magnetic resonance imaging of tumors using low-dose systemic deuterated water labeling.

Frontiers in oncology·2026
Same author

Serum protein profiles differ with adalimumab and ustekinumab treatment in moderately to severely active Crohn's disease.

Journal of Crohn's & colitis·2025
Same author

Targeting FGFR4 abrogates HNF1A-driven metastasis in pancreatic ductal adenocarcinoma.

Molecular cancer·2025
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jul 3, 2025

Author Spotlight: Reprogramming Cancer Cells to iPSCs to Study Disease Progression and Treatment Targets
07:08

Author Spotlight: Reprogramming Cancer Cells to iPSCs to Study Disease Progression and Treatment Targets

Published on: February 2, 2024

799

Alternative Polyadenylation Characterizes Epithelial and Fibroblast Phenotypic Heterogeneity in Pancreatic Ductal

Swati Venkat1, Michael E Feigin1

  • 1Department of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA.

Cancers
|February 10, 2024
PubMed
Summary
This summary is machine-generated.

Alternative polyadenylation in 3' untranslated regions (3' UTR-APA) drives tumor cell heterogeneity. This mechanism influences gene expression, impacting cancer progression and cell states in pancreatic ductal adenocarcinoma (PDAC).

Keywords:
alternative polyadenyationgene regulationpancreatic cancer

More Related Videos

Pancreatic Tissue Dissection to Isolate Viable Single Cells
08:04

Pancreatic Tissue Dissection to Isolate Viable Single Cells

Published on: May 26, 2023

2.7K
Isolation and Characterization of Patient-derived Pancreatic Ductal Adenocarcinoma Organoid Models
08:43

Isolation and Characterization of Patient-derived Pancreatic Ductal Adenocarcinoma Organoid Models

Published on: January 14, 2020

11.3K

Related Experiment Videos

Last Updated: Jul 3, 2025

Author Spotlight: Reprogramming Cancer Cells to iPSCs to Study Disease Progression and Treatment Targets
07:08

Author Spotlight: Reprogramming Cancer Cells to iPSCs to Study Disease Progression and Treatment Targets

Published on: February 2, 2024

799
Pancreatic Tissue Dissection to Isolate Viable Single Cells
08:04

Pancreatic Tissue Dissection to Isolate Viable Single Cells

Published on: May 26, 2023

2.7K
Isolation and Characterization of Patient-derived Pancreatic Ductal Adenocarcinoma Organoid Models
08:43

Isolation and Characterization of Patient-derived Pancreatic Ductal Adenocarcinoma Organoid Models

Published on: January 14, 2020

11.3K

Area of Science:

  • Cancer Biology
  • Molecular Biology
  • Genomics

Background:

  • Human tumors exhibit significant transcriptional variability, leading to diverse cancer cell states.
  • This heterogeneity influences tumor progression and treatment response.
  • The mechanistic drivers of this cellular diversity remain incompletely understood.

Purpose of the Study:

  • To investigate the role of 3' untranslated region alternative polyadenylation (3' UTR-APA) in driving cancer cell phenotypic heterogeneity.
  • To analyze 3' UTR-APA patterns in pancreatic ductal adenocarcinoma (PDAC) cell states.
  • To determine if 3' UTR-APA can characterize distinct tumor cell phenotypes.

Main Methods:

  • Analysis of the largest single-cell human pancreatic ductal adenocarcinoma (PDAC) dataset.
  • Resolution of 3' UTR-APA patterns across different PDAC cell states.
  • Correlation of 3' UTR-APA events with gene expression and cell-state-specific markers.

Main Results:

  • Increased proximal 3' UTR-APA is associated with PDAC progression.
  • Distinct 3' UTR-APA patterns characterize metastatic epithelial and inflammatory fibroblast subpopulations.
  • Significant 3' UTR shortening events correlate with increased expression of cell-state-specific genes.

Conclusions:

  • 3' UTR-APA serves as a key mechanism driving phenotypic heterogeneity in cancer.
  • Understanding 3' UTR-APA provides insights into cancer progression and cellular diversity.
  • Targeting 3' UTR-APA may offer novel therapeutic strategies for PDAC.