Comparison of PIV and Other Immune Inflammation Markers of Oncological and Survival Outcomes in Patients Undergoing Radical Cystectomy
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View abstract on PubMed
Summary
This summary is machine-generated.Pan-immune inflammation value (PIV) and systemic immune inflammation index (SII) can predict outcomes in bladder cancer patients undergoing radical cystectomy. Higher PIV indicates a worse prognosis, highlighting its potential as a prognostic marker.
Area Of Science
- Oncology
- Immunology
- Biomarkers
Background
- Inflammation is a key factor in cancer initiation and progression.
- Prognostic markers are crucial for managing bladder cancer patients.
Purpose Of The Study
- To compare pan-immune inflammation value (PIV) with established markers (SII, NLR) for predicting prognosis in bladder cancer patients treated with radical cystectomy.
- To evaluate the predictive capabilities of PIV, SII, and NLR for tumor characteristics and patient survival.
Main Methods
- Retrospective analysis of 193 patients undergoing radical cystectomy for bladder cancer.
- Assessment of preoperative PIV, SII, and NLR.
- Multivariable logistic and Cox regression analyses to determine predictive values for lymph node infiltration, tumor stage, and survival (RFS, CSS, OS).
Main Results
- Both SII and PIV correlated with lymph node infiltration, aggressive tumor stage, and non-organ-confined disease.
- Higher PIV was significantly associated with reduced Relapse-Free Survival (RFS) and Overall Survival (OS) in both pre- and post-operative analyses.
- Optimal PIV cut-off for RFS was determined as 340.96 × 10^9/L.
Conclusions
- PIV and SII are similar and may serve as independent predictors of aggressive bladder cancer.
- These markers can predict worse survival outcomes in patients undergoing radical cystectomy.
- PIV shows significant prognostic value for bladder cancer patients.
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