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Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
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The Amager Project IV: suicidal behavior and aftercare: real world data (RWD) from a prospective observational

August G Wang1,2, Titia Lahoz1, Marianne Hvid1

  • 1Centre of Psychiatry Amager, Copenhagen University Hospital, Copenhagen, Denmark.

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The OPAC approach effectively reduced suicide attempts in a real-world setting, confirming previous RCT findings. Key risk factors include prior attempts and substance abuse, highlighting the need for targeted interventions.

Keywords:
RCT studySuicidepreventionreal-world data (RWD)suicide risk factors

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Area of Science:

  • Psychiatry and Mental Health
  • Public Health
  • Clinical Research

Background:

  • The Outreach, Problem Solving, Adherence, and Continuity (OPAC) approach demonstrated efficacy in a prior randomized controlled trial (RCT) for suicide attempt aftercare.
  • This study investigated the OPAC method in a real-world data (RWD) clinical setting.

Purpose of the Study:

  • To validate RCT findings on the OPAC approach using real-world evidence (RWE).
  • To assess the long-term prospects and effectiveness of the OPAC method in clinical practice.

Main Methods:

  • A real-world data study involving 506 patients, including those with prior suicide attempts (Group 1) and suicide ideation (Group 2).
  • Follow-up duration of 5 years with Kaplan-Meier survival analysis and risk factor calculation.

Main Results:

  • A decline in survival accelerated after 3 years; 5-year attempted suicide rates were 18% for Group 1 and 10% for Group 2.
  • Identified risk factors for 5-year outcomes included previous suicide attempts, parental or self-reported alcohol/drug abuse, and poor social networks.
  • Both patient groups receiving the OPAC approach showed better outcomes than the control group from the prior RCT.

Conclusions:

  • The OPAC approach's effectiveness was confirmed in a daily clinical setting.
  • Addressing risk factors such as previous suicide attempts, substance abuse, and poor social networks is crucial.
  • Enhanced interventions focusing on belongingness and substance abuse treatment are recommended to prevent relapse.