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CO2-Mediated Alkali-Neutralization Curdlan Hydrogels for Potential Wound Healing Application
Haiyan Wang1, Bohao Yin2, Wenjun Sun3
1Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, College of Biological Science and Medical Engineering, Donghua University, Shanghai 201620, P.R. China.
Biomacromolecules
|February 10, 2024
Summary
This study presents a simple, low-cost method to create Curdlan (CR) hydrogels for wound healing. These natural polysaccharide hydrogels accelerate wound repair by promoting cell growth and tissue regeneration without harmful chemicals.
Area of Science:
- Biomaterials Science
- Polymer Chemistry
- Regenerative Medicine
Background:
- Natural polysaccharides are ideal for wound dressings due to biocompatibility and lack of toxic cross-linkers.
- Fabricating such hydrogels easily and affordably remains a significant challenge.
Purpose of the Study:
- To develop a facile and cost-effective method for producing pure Curdlan (CR) physical hydrogels.
- To evaluate the potential of these CR hydrogels as advanced wound dressings.
Main Methods:
- Curdlan (CR) powders were dissolved in alkali solutions (NaOH or Na3PO4) and exposed to air to form hydrogels.
- Physicochemical properties, cell compatibility (L929 cells), and in vivo wound healing efficacy were assessed.
Main Results:
- A CO2-mediated alkali-neutralization method successfully produced CR hydrogels without external cross-linking agents.
- The hydrogels exhibited tunable porous structures, enhanced gel strength, flexibility, and ideal swelling and degradation properties.
- In vivo studies demonstrated accelerated wound healing, increased collagen deposition, and enhanced neovascularization.
Conclusions:
- This work provides a safe, facile, and cost-effective manufacturing procedure for high-performance pure CR physical hydrogels.
- The developed CR hydrogels show significant promise as advanced wound dressing materials for therapeutic applications.
