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  11. Mesenchymal Stromal Cells (mscs) As A Therapeutic Agent Of Inflammatory Disease And Infectious Covid-19 Virus: Live Or Dead Mesenchymal?

Mesenchymal stromal cells (MSCs) as a therapeutic agent of inflammatory disease and infectious COVID-19 virus: live or dead mesenchymal?

Ramiar Kamal Kheder1,2, Omeed Darweesh3,4, Bashdar Mahmud Hussen5,6

  • 1Medical Laboratory Science Department, College of Science, University of Raparin, Sulaymaniyah, Iraq.

Molecular Biology Reports
|February 10, 2024

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View abstract on PubMed

Summary
This summary is machine-generated.

Dead mesenchymal stromal cells (MSCs) are more effective than live MSCs for treating COVID-19. Dead MSCs provide superior immune regulation and prolonged therapeutic presence, aiding recovery from immune-inflammatory disorders.

Area of Science:

  • Immunology
  • Regenerative Medicine
  • Infectious Diseases

Background:

  • COVID-19 causes widespread immune-inflammatory disorders and lung dysfunction.
  • Mesenchymal stromal cells (MSCs) show therapeutic potential due to anti-inflammatory properties.
  • MSCs are sourced from various tissues and used for conditions like diabetes and autoimmune diseases.

Purpose of the Study:

  • To compare the efficacy of live versus dead mesenchymal stromal cells (MSCs) in treating COVID-19 patients.
  • To investigate the immunomodulatory effects and persistence of live and dead MSCs.

Main Methods:

  • Administration of live and dead MSCs to COVID-19 patients.
  • Analysis of immune regulation markers (T-reg, B-reg, IL-10) and cell presence.
  • Evaluation of MSCs' interaction with monocytes and macrophages.
Keywords:
COVID-19Inflammatory diseaseLive MSCs and dead MSCsMesenchymal stem cells (MSCs)

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Main Results:

  • Dead MSCs demonstrated superior immune regulation, including higher T-reg, B-reg, and IL-10 levels compared to live MSCs.
  • Dead and apoptotic MSCs exhibited prolonged presence in patients.
  • Enhanced capture of dead/apoptotic MSCs by monocytes and macrophages was observed, contributing to their extended therapeutic effect.

Conclusions:

  • Dead MSCs offer advantages over live MSCs for COVID-19 treatment.
  • The enhanced immunomodulatory capacity and prolonged persistence of dead MSCs are key to their therapeutic benefits.
  • Dead MSCs represent a promising therapeutic strategy for managing COVID-19-related immune-inflammatory complications.