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Nomogram combining pre-operative clinical characteristics and spectral CT parameters for predicting the WHO/ISUP

Hongyu Zhang1,2,3, Fukai Li1,2,3, Mengyuan Jing1,2,3

  • 1Second Clinical School, Lanzhou University, Lanzhou, China.

Abdominal Radiology (New York)
|February 10, 2024
PubMed
Summary

A new clinical-spectral computed tomography (CT) nomogram accurately predicts clear cell renal cell carcinoma (ccRCC) grading before surgery. This tool combines patient age, immune markers, and CT scan data to improve preoperative pathological grade assessment.

Keywords:
Clear cell renal cell carcinomaNomogramSpectral CTThe systemic immune-inflammatory indexWHO/ISUP grading

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Area of Science:

  • Radiology
  • Oncology
  • Medical Imaging

Background:

  • Clear cell renal cell carcinoma (ccRCC) grading is crucial for treatment planning.
  • Accurate preoperative grading of ccRCC remains a challenge.
  • Novel imaging biomarkers are needed for non-invasive tumor assessment.

Purpose of the Study:

  • To develop and validate a clinical-spectral computed tomography (CT) nomogram for preoperative prediction of WHO/ISUP pathological grade in ccRCC.
  • To integrate clinical characteristics and spectral CT parameters for enhanced predictive accuracy.

Main Methods:

  • Retrospective analysis of 73 ccRCC patients who underwent spectral CT.
  • Multivariate logistic regression to identify independent predictors.
  • Development of a nomogram combining clinical and spectral CT data.
  • Assessment of predictive performance using the area under the curve (AUC).

Main Results:

  • Age, systemic immune-inflammation index (SII), and cortex phase spectral slope (CP-K) were independent predictors of high-grade ccRCC.
  • The clinical-spectral-CT nomogram achieved a high AUC of 0.933.
  • The model demonstrated excellent calibration and good fitness (Hosmer-Lemeshow test).

Conclusions:

  • The developed clinical-spectral-CT nomogram shows significant potential for accurate preoperative WHO/ISUP grading of ccRCC.
  • This tool can aid in non-invasive assessment and guide clinical decision-making for ccRCC patients.