Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cartilage morphogenesis in vitro.

C W Archer, P Rooney, C P Cottrill

    Journal of Embryology and Experimental Morphology
    |December 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Investigating cartilage formation in vitro, this study found that cell configuration and the presence of other cell types, not intrinsic cell potential, dictate cartilage morphogenesis. This challenges previous tissue-specific theories.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    A combined physicochemical approach towards human tenocyte phenotype maintenance.

    Materials today. Bio·2021
    Same author

    Laparoscopic drainage of an intra-abdominal desmoid abscess - a video vignette.

    Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland·2020
    Same author

    Investigation of a foodborne outbreak of Shigella sonnei in Ireland and Northern Ireland, December 2016: the benefits of cross-border collaboration and commercial sales data.

    Public health·2020
    Same author

    Extracellular Vesicles in the Synovial Joint: Is there a Role in the Pathophysiology of Osteoarthritis?

    Malaysian orthopaedic journal·2019
    Same author

    Comparison of bone marrow component removal from processed femoral head bone from living and deceased donors: presence of geodes in living donor bone can prevent maximum removal of marrow components.

    Cell and tissue banking·2018
    Same author

    The epidemiology and management of candidemia in Northern Ireland during 2002-2011, including a 12-month enhanced case review.

    Medical mycology·2018

    Area of Science:

    • Developmental Biology
    • Cell Biology
    • Tissue Engineering

    Background:

    • Prechondrogenic mesenchyme from different embryonic sources exhibits distinct cartilage formation patterns in vitro.
    • Previous research suggested tissue-specific intrinsic morphogenetic potential for cartilage formation.

    Purpose of the Study:

    • To investigate the morphogenetic capacity of prechondrogenic mesenchyme from scleral and limb bud origins.
    • To determine the factors influencing cartilage morphogenesis in high-density micromass cultures.

    Main Methods:

    • High-density micromass cultures of prechondrogenic mesenchyme.
    • Manipulation of cell density at inoculation to alter cell configuration.
    • Variation of the relative amount of prechondrogenic mesenchyme in cultures.

    Related Experiment Videos

    Main Results:

    • Scleral mesenchyme formed cartilage sheets, while limb bud mesenchyme formed nodules, confirming prior observations.
    • Altering cell density and the proportion of mesenchyme significantly changed cartilage morphogenesis.
    • Cartilage morphogenesis was found to be dependent on cell configuration and the presence of non-chondrogenic cells.

    Conclusions:

    • Cartilage morphogenesis in vitro is not solely determined by the intrinsic potential of chondrogenic cells.
    • Cell configuration and the cellular microenvironment play crucial roles in directing cartilage development.
    • Findings suggest a more dynamic and context-dependent model for cartilage tissue formation.