JoVE - Journal of Visualized Experiments
JoVE Visualize
Contact Us

In-vitro assessment of a novel intraocular lens made of crosslinked polyisobutylene

  • 0The David J. Apple International Laboratory for Ocular Pathology, Department of Ophthalmology, University Hospital of Heidelberg, Heidelberg, Germany.
Journal of the Mechanical Behavior of Biomedical Materials +

|

February 10, 2024

|

February 10, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

The new Eyedeal® intraocular lens (IOL) made of crosslinked polyisobutylene (xPIB) demonstrates superior resistance to glistening compared to AcrySof® lenses. Laboratory tests confirm its material and optical quality are equivalent to current IOLs.

Area Of Science

  • Ophthalmology
  • Biomaterials Science
  • Optical Engineering

Background

  • Intraocular lenses (IOLs) are crucial for vision restoration after cataract surgery.
  • Material properties and optical quality of IOLs significantly impact patient outcomes.
  • Glistening, or microvacuoles, in IOLs can affect optical performance and long-term safety.

Purpose Of The Study

  • To characterize the material and optical properties of the novel Eyedeal® intraocular lens (IOL).
  • To evaluate the performance of the first IOL made from crosslinked polyisobutylene (xPIB).
  • To compare the Eyedeal® lens with a control AcrySof® lens, focusing on glistening and optical quality.

Main Methods

  • Accelerated aging process to induce glistening, with density quantified.
  • Sessile drop method to measure the contact angle of the IOL material.
  • Scanning electron microscopy (SEM) for surface analysis.
  • Optical quality assessment using modulation transfer function (MTF) and labeled power.

Main Results

  • Eyedeal® lenses exhibited significantly lower glistening density (7.46 MV/mm²) compared to AcrySof® (142.42 MV/mm²).
  • The contact angle for Eyedeal® was 97.2°, indicating a more hydrophobic surface than AcrySof®.
  • SEM revealed Eyedeal® surfaces comparable to modern acrylic IOLs; optical power and MTF met ISO standards.

Conclusions

  • The Eyedeal® lens, made of xPIB, shows material and optical equivalence to current acrylic IOLs.
  • Eyedeal® demonstrates superior performance regarding glistening density compared to the control AcrySof® lens.
  • This new IOL material presents a promising alternative for cataract surgery with improved glistening resistance.

Keywords: