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Related Experiment Videos

Cellular antimicrobial immunity.

F M Collins

    CRC Critical Reviews in Microbiology
    |January 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Acquired resistance to infectious disease involves humoral and cellular immunity, with T-lymphocytes and B-lymphocytes playing key roles. Understanding these immune mechanisms is crucial for effective vaccine development and disease prevention.

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    Area of Science:

    • Immunology
    • Cellular Biology
    • Vaccinology

    Background:

    • Acquired resistance to infectious diseases is mediated by humoral and/or cellular immune mechanisms.
    • The host immune response involves phagocytic cells, thymus-dependent (T) lymphocytes, and thymus-independent (B) lymphocytes.
    • Different mucosal sites exhibit distinct cellular interactions for immune response induction.

    Purpose of the Study:

    • To discuss cellular interactions in immune response induction across various tissues.
    • To outline the role of vaccines in acquired resistance.
    • To detail the functions of phagocytic cells, T-lymphocytes, and B-lymphocytes in immunity.

    Main Methods:

    • Review of cellular interactions in immune response induction.
    • Analysis of vaccine efficacy in inducing acquired resistance.

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  • Examination of cell fractionation and surface marker identification for immune cell studies.

    • Main Results:

    • Phagocytic cells, T-lymphocytes, and B-lymphocytes are critical for host defense.
    • Cellular immunity, including delayed-type hypersensitivity (DTH) and cell-mediated immunity (CMI), is essential for eliminating intracellular parasites.
    • Killed vaccines primarily induce humoral responses, often without CMI, limiting protection against natural disease.

    Conclusions:

    • Humoral and cellular immunity, orchestrated by distinct cell types, are vital for combating infectious diseases.
    • Vaccine strategies must consider both humoral and cellular immune components for optimal efficacy.
    • Suppressor B- and T-cells modulate immune responses, influencing tolerance, autoimmunity, and memory.