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Updated: Jul 3, 2025

In Vitro Selection of Engineered Transcriptional Repressors for Targeted Epigenetic Silencing
Published on: May 5, 2023
Engineering transcriptional regulation for cell-based therapies.
Matthias Recktenwald1, Evan Hutt1, Leah Davis1
1Department of Biomedical Engineering, Rowan University, Glassboro, NJ 08028, USA.
Synthetic biology tools can now control cellular functions using external signals. This review explores transmembrane receptors for precise gene regulation in cell therapies, enhancing cancer treatment and regenerative medicine.
Area of Science:
- Synthetic biology
- Cellular engineering
- Molecular biology
Background:
- Gene transcription and regulation are key cellular functions for therapeutic applications.
- Transmembrane receptor platforms, inspired by CAR T-cell therapies, sense extracellular signals.
- Integrating receptors with transcriptional control is crucial for advanced cell therapies.
Conclusions:
- Transmembrane receptors offer revolutionary potential for cell therapies, including cancer and regenerative medicine.
- Further development is needed to expand capabilities and refine control of gene regulation.
- Precise control of transcription via external stimuli is a promising frontier in therapeutic cell engineering.
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